Effect of Pingchuan Guben decoction on patients with chronic obstructive pulmonary disease: Results from a randomized comparative effectiveness research trial

  • Authors:
    • Cheng‑Liang Qian
    • Rong Fan
  • View Affiliations

  • Published online on: August 24, 2017     https://doi.org/10.3892/etm.2017.5018
  • Pages: 3915-3925
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Chronic obstructive pulmonary disease (COPD) is known to be a systemic low‑grade ongoing inflammation exerting major health and economic burden worldwide. Complementary and alternative medicines, such as Traditional Chinese Medicine, are widely used for the treatment of patients with COPD. The present study was designed to investigate the efficacy of Pingchuan Guben decoction on patients with COPD through a double‑blinded, open‑labeled, randomized controlled trial. A total of 86 patients were randomly assigned to two groups, with 43 patients in the intervention group and 43 cases in the control group. The patients in the control group were treated with conventional western medicine, and the intervention group received a combination of conventional western medicine and Pingchuan Guben decoction. After 12 weeks of treatment, the mean 6‑minute walking distance, forced expiratory volume in 1 sec (FEV1), forced vital capacity (FVC) and FEV1/FVC in the intervention group were significantly higher than those of the control group (P<0.05). The levels of inflammation factors and protease molecules were significantly ameliorated in the intervention group compared with the control group (P<0.05). The levels of Kelch‑like ECH‑associated protein 1 (Keap1), nuclear factor‑E2‑related factor‑2 (Nrf2), superoxide anions, malondialdehyde, glutathione S‑transferase and glutathione peroxidase were significantly more improved in the intervention group compared with those in the control group over the 12‑week study period (P<0.05). Therefore, combinations of western medicine with Pingchuan Guben decoction may exert therapeutic effects on patients with COPD via modulations of inflammation factors and protease molecules, as well as the activation of the Keap1/Nrf2 signaling pathway.

Related Articles

Journal Cover

October-2017
Volume 14 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Qian CL and Qian CL: Effect of Pingchuan Guben decoction on patients with chronic obstructive pulmonary disease: Results from a randomized comparative effectiveness research trial. Exp Ther Med 14: 3915-3925, 2017
APA
Qian, C., & Qian, C. (2017). Effect of Pingchuan Guben decoction on patients with chronic obstructive pulmonary disease: Results from a randomized comparative effectiveness research trial. Experimental and Therapeutic Medicine, 14, 3915-3925. https://doi.org/10.3892/etm.2017.5018
MLA
Qian, C., Fan, R."Effect of Pingchuan Guben decoction on patients with chronic obstructive pulmonary disease: Results from a randomized comparative effectiveness research trial". Experimental and Therapeutic Medicine 14.4 (2017): 3915-3925.
Chicago
Qian, C., Fan, R."Effect of Pingchuan Guben decoction on patients with chronic obstructive pulmonary disease: Results from a randomized comparative effectiveness research trial". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3915-3925. https://doi.org/10.3892/etm.2017.5018