Geniposide attenuates epilepsy symptoms in a mouse model through the PI3K/Akt/GSK‑3β signaling pathway

  • Authors:
    • Hongtao Wei
    • Guanghui Duan
    • Jianxun He
    • Qinglong Meng
    • Yuxian Liu
    • Wanqiang Chen
    • Yongpeng Meng
  • View Affiliations

  • Published online on: November 14, 2017     https://doi.org/10.3892/etm.2017.5512
  • Pages:1136-1142
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Abstract

Previous reports on the pharmacological actions of geniposide have indicated that it has anti‑asthmatic, anti‑inflammatory and analgesic effects in the liver and gallbladder, and therapeutic effects in neurological, cardiovascular and cerebrovascular diseases. The results of the current study demonstrate that geniposide attenuates epilepsy in a mouse model through the phosphoinositide 3‑kinase (PI3K)/protein kinase B (Akt)/glycogen synthase kinase‑3β (GSK‑3β) signaling pathway. A mouse model of epilepsy was induced by maximal electric shock (50 mA, 50 Hz, 1 sec). Epilepsy mice were intragastrically administered with 0, 5, 10 or 20 mg/kg geniposide. Geniposide significantly reduced the incidence and significantly increased the latency of clonic seizures in epileptic mice compared with non‑treated epileptic mice (both P<0.01). Geniposide treatment significantly inhibited cyclooxygenase‑2 mRNA expression in epilepsy mice (P<0.01). Furthermore, geniposide significantly suppressed the protein expression of activator protein 1, increased the activation of Akt and increased the protein expression of GSK‑3β and PI3K in epilepsy mice (all P<0.01). These results suggest that geniposide attenuates epilepsy in mice through the PI3K/Akt/GSK‑3β signaling pathway.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Wei, H., Duan, G., He, J., Meng, Q., Liu, Y., Chen, W., & Meng, Y. (2018). Geniposide attenuates epilepsy symptoms in a mouse model through the PI3K/Akt/GSK‑3β signaling pathway. Experimental and Therapeutic Medicine, 15, 1136-1142. https://doi.org/10.3892/etm.2017.5512
MLA
Wei, H., Duan, G., He, J., Meng, Q., Liu, Y., Chen, W., Meng, Y."Geniposide attenuates epilepsy symptoms in a mouse model through the PI3K/Akt/GSK‑3β signaling pathway". Experimental and Therapeutic Medicine 15.1 (2018): 1136-1142.
Chicago
Wei, H., Duan, G., He, J., Meng, Q., Liu, Y., Chen, W., Meng, Y."Geniposide attenuates epilepsy symptoms in a mouse model through the PI3K/Akt/GSK‑3β signaling pathway". Experimental and Therapeutic Medicine 15, no. 1 (2018): 1136-1142. https://doi.org/10.3892/etm.2017.5512