Open Access

Expression of tissue inhibitor of metalloproteinases-1 and B-cell lymphoma-2 in the synovial membrane in patients with knee osteoarthritis

  • Authors:
    • Xiaomiao Li
    • Xiaodong Fu
    • Yingjian Gao
    • Hao Li
    • Weili Wang
    • Yi Shen
  • View Affiliations

  • Published online on: November 8, 2017     https://doi.org/10.3892/etm.2017.5462
  • Pages:885-889
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: HTML 0 views | PDF 0 views
0

Abstract

The purpose of this study was to determine the expression and impact of tissue inhibitor of metalloproteinases-1 (TIMP-1) and B-cell lymphoma-2 (Bcl-2) in knee osteoarthritis (KOA). We collected synovial fluids from the knee joint of 70 KOA patients and 30 controls. The expression levels of TIMP-1 and Bcl-2 were significantly higher in KOA patients than those in the control group (P<0.01). We also found positive correlation between the severity of KOA and the expression level of TIMP-1 (r=0.8027, P<0.05) and and Bcl-2 (r=0.5336, P<0.05). However, we found no correlation between the expression levels of TIMP-1 and Bcl-2 in the synovial membranes of KOA patients (P>0.05). Both TIMP-1 and Bcl-2 are expressed at high levels in the synovial membrane with KOA, and are closely related to the occurrence and development of KOA. Thus, detection of TIMP-1 and Bcl-2 in KOA patients can be helpful in diagnosing the state of KOA.

Related Articles

Journal Cover

January 2018
Volume 15 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Li, X., Fu, X., Gao, Y., Li, H., Wang, W., & Shen, Y. (2018). Expression of tissue inhibitor of metalloproteinases-1 and B-cell lymphoma-2 in the synovial membrane in patients with knee osteoarthritis. Experimental and Therapeutic Medicine, 15, 885-889. https://doi.org/10.3892/etm.2017.5462
MLA
Li, X., Fu, X., Gao, Y., Li, H., Wang, W., Shen, Y."Expression of tissue inhibitor of metalloproteinases-1 and B-cell lymphoma-2 in the synovial membrane in patients with knee osteoarthritis". Experimental and Therapeutic Medicine 15.1 (2018): 885-889.
Chicago
Li, X., Fu, X., Gao, Y., Li, H., Wang, W., Shen, Y."Expression of tissue inhibitor of metalloproteinases-1 and B-cell lymphoma-2 in the synovial membrane in patients with knee osteoarthritis". Experimental and Therapeutic Medicine 15, no. 1 (2018): 885-889. https://doi.org/10.3892/etm.2017.5462