Open Access

Expression of MMP-9 and IL-6 in patients with subarachnoid hemorrhage and the clinical significance

  • Authors:
    • Luchen Wang
    • Ziyun Gao
  • View Affiliations

  • Published online on: November 23, 2017     https://doi.org/10.3892/etm.2017.5553
  • Pages:1510-1514
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The purpose of the present study was to investigate the expression of matrix metalloproteinase-9 (MMP-9) and interleukin-6 (IL-6) in patients with subarachnoid hemorrhage (SAH) and the clinical significance thereof. Forty-three patients with SAH and 23 healthy individuals were enrolled in this study. Patients were divided into the cerebral vasospasm (CVS) and non-cerebral vasospasm (non-CVS) groups, or the good and poor prognosis groups. Serum levels of MMP-9 and IL-6 were detected by ELISA. Expression levels of MMP-9 and IL-6 mRNAs were detected by RT‑qPCR. Expression levels of MMP-9 and IL-6 were elevated with the increase of grades as determined by the Hunt‑Hess grading method. Serum levels of MMP-9 and IL-6 in the CVS and poor prognosis groups were significantly higher than those in the control group. Expression levels of MMP-9 and IL-6 in the CVS group were significantly higher than those in the non-CVS group (P<0.05). Compared with the good prognosis group, the expression levels of MMP-9 and IL-6 were significantly increased in the poor prognosis group at 1, 4, 7 and 10 days after SAH (P<0.05). Additionally, the expression level of MMP-9 was significantly positively correlated with that of IL-6 (P<0.05). Expression levels of MMP-9 and IL-6 were significantly increased in patients with SAH, and the expression level of MMP-9 was positively correlated with that of IL-6. Thus, MMP-9 and IL-6 are involved in the development of SAH.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Wang, L., & Wang, L. (2018). Expression of MMP-9 and IL-6 in patients with subarachnoid hemorrhage and the clinical significance. Experimental and Therapeutic Medicine, 15, 1510-1514. https://doi.org/10.3892/etm.2017.5553
MLA
Wang, L., Gao, Z."Expression of MMP-9 and IL-6 in patients with subarachnoid hemorrhage and the clinical significance". Experimental and Therapeutic Medicine 15.2 (2018): 1510-1514.
Chicago
Wang, L., Gao, Z."Expression of MMP-9 and IL-6 in patients with subarachnoid hemorrhage and the clinical significance". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1510-1514. https://doi.org/10.3892/etm.2017.5553