Open Access

Identification of core pathways based on attractor and crosstalk in ischemic stroke

  • Authors:
    • Xiufang Diao
    • Aijuan Liu
  • View Affiliations

  • Published online on: November 24, 2017     https://doi.org/10.3892/etm.2017.5563
  • Pages:1520-1524
  • Copyright: © Diao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ischemic stroke is a leading cause of mortality and disability around the world. It is an important task to identify dysregulated pathways which infer molecular and functional insights existing in high‑throughput experimental data. Gene expression profile of E-GEOD-16561 was collected. Pathways were obtained from the database of Kyoto Encyclopedia of Genes and Genomes and Retrieval of Interacting Genes was used to download protein-protein interaction sets. Attractor and crosstalk approaches were applied to screen dysregulated pathways. A total of 20 differentially expressed genes were identified in ischemic stroke. Thirty-nine significant differential pathways were identified according to P<0.01 and 28 pathways were identified with RP<0.01 and 17 pathways were identified with impact factor >250. On the basis of the three criteria, 11 significant dysfunctional pathways were identified. Among them, Epstein-Barr virus infection was the most significant differential pathway. In conclusion, with the method based on attractor and crosstalk, significantly dysfunctional pathways were identified. These pathways are expected to provide molecular mechanism of ischemic stroke and represents a novel potential therapeutic target for ischemic stroke treatment.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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APA
Diao, X., & Diao, X. (2018). Identification of core pathways based on attractor and crosstalk in ischemic stroke. Experimental and Therapeutic Medicine, 15, 1520-1524. https://doi.org/10.3892/etm.2017.5563
MLA
Diao, X., Liu, A."Identification of core pathways based on attractor and crosstalk in ischemic stroke". Experimental and Therapeutic Medicine 15.2 (2018): 1520-1524.
Chicago
Diao, X., Liu, A."Identification of core pathways based on attractor and crosstalk in ischemic stroke". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1520-1524. https://doi.org/10.3892/etm.2017.5563