Anterior spinal instrumentation combining a prosthetic disc nucleus with a flexible stabilization device: Manufacture and use in intervertebral disc repair

  • Authors:
    • Da Bao
    • Dawei Li
  • View Affiliations

  • Published online on: January 12, 2018     https://doi.org/10.3892/etm.2018.5745
  • Pages: 3040-3044
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Abstract

Artificial disc replacement alone is unable to completely cure cervical degenerative diseases; thus, a stabilization device markedly improves patient recovery. In order to meet this requirement, an anterior spinal instrumentation combining a prosthetic disc nucleus with a flexible stabilization device (ASI combining PDN/FD) was developed. An artificial disc was designed and manufactured using polyvinyl alcohol hydrogel (PVA‑H) with a repeated freeze‑melting technique, and subsequently the dehydration and swelling properties of the PVA‑H were investigated. A canine animal model was then used to compare the differences in the degeneration of cervical discs adjacent to the operative segment with PDN/FD against a plate fixation system, without the interferences of brace intensity, which was ensured by pressure monitoring the dog's intervertebral disc adjacent to operative segments. The in vivo results demonstrated a clear decrease in the degeneration of the adjacent disc with the use of PDN/FD as compared with the plate fixation system. In conclusion, PDN/FD may offer a promising method for the treatment of cervical degenerative disease.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Bao D and Bao D: Anterior spinal instrumentation combining a prosthetic disc nucleus with a flexible stabilization device: Manufacture and use in intervertebral disc repair. Exp Ther Med 15: 3040-3044, 2018
APA
Bao, D., & Bao, D. (2018). Anterior spinal instrumentation combining a prosthetic disc nucleus with a flexible stabilization device: Manufacture and use in intervertebral disc repair. Experimental and Therapeutic Medicine, 15, 3040-3044. https://doi.org/10.3892/etm.2018.5745
MLA
Bao, D., Li, D."Anterior spinal instrumentation combining a prosthetic disc nucleus with a flexible stabilization device: Manufacture and use in intervertebral disc repair". Experimental and Therapeutic Medicine 15.3 (2018): 3040-3044.
Chicago
Bao, D., Li, D."Anterior spinal instrumentation combining a prosthetic disc nucleus with a flexible stabilization device: Manufacture and use in intervertebral disc repair". Experimental and Therapeutic Medicine 15, no. 3 (2018): 3040-3044. https://doi.org/10.3892/etm.2018.5745