The investigation of immunomodulatory activities of Gloeostereum incaratum polysaccharides in cyclophosphamide-induced immunosuppression mice

  • Authors:
    • Di Wang
    • Qian Li
    • Yidi Qu
    • Mengya Wang
    • Lanzhou Li
    • Yang Liu
    • Yu Li
  • View Affiliations

  • Published online on: January 30, 2018     https://doi.org/10.3892/etm.2018.5810
  • Pages: 3633-3638
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Abstract

Gloeostereum incarnatum, a precious edible mushroom, displays anti‑bacterial and anti‑inflammatory activities; however, its immunomodulatory effect has not been studied yet. The present study aimed to investigate whether polysaccharide compositions of G. incarnatum polysaccharides (GIPS) possess immunomodulatory and immuno‑enhancing effects in a Cyclophosphamide monohydrate (CTX)‑induced BALB/c mice model. The 28‑day GIPS administration at doses of 0.1, 0.3 and 0.9 g/kg remarkably reversed the bodyweight loss, increased the thymic index and promoted T lymphocyte proliferation in CTX‑induced immunosuppressed mice. GIPS significantly raised the serum levels of immunoglobulin (Ig)A and IgG, promoted the production of interleukins (ILs), including IL‑2, IL‑3 and IL‑6, interferons, including interferon (IFN)‑α and IFN‑γ, and monocyte chemotactic protein 1 in the spleen, which resulted in accelerating recovery of immunosuppression. Finally, GIPS showed anti‑oxidative effects indicated by the increased superoxide dismutase levels in the serum and spleen, and the reduced level of reactive oxygen species in the spleen. The results of the current study demonstrated that GIPS positively adjusts the immune system, which may serve as a potential immunostimulatory agent.
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April-2018
Volume 15 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang D, Li Q, Qu Y, Wang M, Li L, Liu Y and Li Y: The investigation of immunomodulatory activities of Gloeostereum incaratum polysaccharides in cyclophosphamide-induced immunosuppression mice. Exp Ther Med 15: 3633-3638, 2018
APA
Wang, D., Li, Q., Qu, Y., Wang, M., Li, L., Liu, Y., & Li, Y. (2018). The investigation of immunomodulatory activities of Gloeostereum incaratum polysaccharides in cyclophosphamide-induced immunosuppression mice. Experimental and Therapeutic Medicine, 15, 3633-3638. https://doi.org/10.3892/etm.2018.5810
MLA
Wang, D., Li, Q., Qu, Y., Wang, M., Li, L., Liu, Y., Li, Y."The investigation of immunomodulatory activities of Gloeostereum incaratum polysaccharides in cyclophosphamide-induced immunosuppression mice". Experimental and Therapeutic Medicine 15.4 (2018): 3633-3638.
Chicago
Wang, D., Li, Q., Qu, Y., Wang, M., Li, L., Liu, Y., Li, Y."The investigation of immunomodulatory activities of Gloeostereum incaratum polysaccharides in cyclophosphamide-induced immunosuppression mice". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3633-3638. https://doi.org/10.3892/etm.2018.5810