Open Access

Decreased expression of sirtuin 3 protein correlates with early stage chronic renal allograft dysfunction in a rat kidney model

  • Authors:
    • Qin Zhou
    • Daoyuan Lv
    • Yue Xia
    • Zhihong Zhao
    • Hequn Zou
  • View Affiliations

  • Published online on: February 28, 2018     https://doi.org/10.3892/etm.2018.5909
  • Pages: 3725-3732
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Chronic renal allograft dysfunction (CRAD) is the primary factor affecting the long‑term survival of patients who have undergone renal transplantation. Oxidative stress and inflammation serve an important role in the pathological damage caused by CRAD in the early post‑transplantation phase. Previous studies have demonstrated that sirtuin 3 (sirt3) protects cells from oxidative stress and inflammation. A model of renal orthotopic transplantation was established in the current study and kidney samples were harvested from the rats 12 weeks following surgery. Compared with the control groups, there were significantly increased levels of serum creatinine, blood urea nitrogen and 24 h urinary protein in the allograft group (P<0.05). Pathological examinations indicated mononuclear cell infiltration and intimal proliferation in the allograft group, which had a higher Banff score compared with the control groups. There were increased levels of malondialdehyde, decreased sirt3 protein expression and decreased superoxide dismutase enzyme activity in the allograft group compared with the control groups (P<0.05). In addition, there was a negative correlation between the expression of sirt3 and 24 h urinary protein excretion, serum creatinine levels, tubulointerstitial mononuclear cell infiltration, smooth muscle cell migration in the vascular wall and Banff scores. Thus, sirt3 may serve an important protective role in the early stage of CRAD.
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April-2018
Volume 15 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhou Q, Lv D, Xia Y, Zhao Z and Zou H: Decreased expression of sirtuin 3 protein correlates with early stage chronic renal allograft dysfunction in a rat kidney model. Exp Ther Med 15: 3725-3732, 2018
APA
Zhou, Q., Lv, D., Xia, Y., Zhao, Z., & Zou, H. (2018). Decreased expression of sirtuin 3 protein correlates with early stage chronic renal allograft dysfunction in a rat kidney model. Experimental and Therapeutic Medicine, 15, 3725-3732. https://doi.org/10.3892/etm.2018.5909
MLA
Zhou, Q., Lv, D., Xia, Y., Zhao, Z., Zou, H."Decreased expression of sirtuin 3 protein correlates with early stage chronic renal allograft dysfunction in a rat kidney model". Experimental and Therapeutic Medicine 15.4 (2018): 3725-3732.
Chicago
Zhou, Q., Lv, D., Xia, Y., Zhao, Z., Zou, H."Decreased expression of sirtuin 3 protein correlates with early stage chronic renal allograft dysfunction in a rat kidney model". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3725-3732. https://doi.org/10.3892/etm.2018.5909