Open Access

Inhibition of prostaglandin E2 protects abdominal aortic aneurysm from expansion through regulating miR-29b-mediated fibrotic ECM expression

  • Authors:
    • Zonglin Han
    • Tangshan Zhang
    • Yuxiang He
    • Gang Li
    • Gang Li
    • Xing Jin
  • View Affiliations

  • Published online on: May 11, 2018     https://doi.org/10.3892/etm.2018.6160
  • Pages: 155-160
  • Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The risk of rupture, the most feared clinical consequence of abdominal aortic aneurysm, increases with the enlargement of aorta. MicroRNA-29b (miR-29b) has emerged as a key modulator of extracellular matrix (ECM) homeostasis and thereby is proposed to play a crucial role in vascular remodeling. However, agents that alter miR-29b expression are relatively inefficient in the aorta, likely due to inferior uptake. Herein we found that miR-29b was upregulated in aortic smooth muscle cells upon prostaglandin E2 (PGE2) stimulation whereas indomethacin treatment downregulated miR-29b expression. In order to obtain insight into the pathological processes associated with the vascular remodeling that accompanies aortic dilatation, we compared expression profiles of several representative ECM components in aortic walls. Notably, PGE2 induced a dramatic decline in these ECM components, which was rescued by introduction of indomethacin. In addition, COL1A1 was validated as a direct target gene of miR-29b by dual-luciferase reporter assay. In aggregate, our study suggests that PGE2 may accelerate ECM degradation through decreasing miR-29b expression. Thus those anti-inflammatory drugs that inhibit PGE2 synthesis represent an effective means of inducing an augmented profibrotic response in the aortic walls and thereby inhibiting aneurysmal expansion.
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July-2018
Volume 16 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Han Z, Zhang T, He Y, Li G, Li G and Jin X: Inhibition of prostaglandin E2 protects abdominal aortic aneurysm from expansion through regulating miR-29b-mediated fibrotic ECM expression. Exp Ther Med 16: 155-160, 2018
APA
Han, Z., Zhang, T., He, Y., Li, G., Li, G., & Jin, X. (2018). Inhibition of prostaglandin E2 protects abdominal aortic aneurysm from expansion through regulating miR-29b-mediated fibrotic ECM expression. Experimental and Therapeutic Medicine, 16, 155-160. https://doi.org/10.3892/etm.2018.6160
MLA
Han, Z., Zhang, T., He, Y., Li, G., Li, G., Jin, X."Inhibition of prostaglandin E2 protects abdominal aortic aneurysm from expansion through regulating miR-29b-mediated fibrotic ECM expression". Experimental and Therapeutic Medicine 16.1 (2018): 155-160.
Chicago
Han, Z., Zhang, T., He, Y., Li, G., Li, G., Jin, X."Inhibition of prostaglandin E2 protects abdominal aortic aneurysm from expansion through regulating miR-29b-mediated fibrotic ECM expression". Experimental and Therapeutic Medicine 16, no. 1 (2018): 155-160. https://doi.org/10.3892/etm.2018.6160