Open Access

Effects of forkhead box protein M1 on trophoblast invasion and its role in preeclampsia development

  • Authors:
    • Xuena Cui
    • Jin'e Xu
    • Yuzhi Ji
    • Xiuhong Song
    • Junhuan Wang
    • Lijuan Zhang
    • Shengmei Yang
    • Yuanhua Ye
  • View Affiliations

  • Published online on: May 18, 2018     https://doi.org/10.3892/etm.2018.6195
  • Pages: 197-203
  • Copyright: © Cui et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to investigate the expression of the forkhead box protein M1 (FOXM1) in the placenta of patients with preeclampsia, and its effect on trophoblasts. A total of 28 patients with preeclampsia and 30 patients without preeclampsia (controls) who underwent cesarean section and were admitted to the Affiliated Hospital of Qingdao University between June 2013 and September 2016 were enrolled in the present study. The expression of FOXM1 in placental tissues was examined by reverse transcription‑quantitative polymerase chain reaction, western blotting and immunohistochemistry. HTR8/SVneo cells were used to measure the in vitro expression of the vascular endothelial growth factor (VEGF). The results demonstrated that FOXM1 expression was downregulated in the placental tissues of patient with preeclampsia (P<0.05). Following the silencing of FOXM1 expression, the proliferation of HTR8/SVneo cells was suppressed. The results of flow cytometry demonstrated that proportion of HTR8/SVneo cells in the G0/G1 phase and the proportion of apoptotic cells increased. The expression of the apoptosis regulator BCL‑2, as well as the expression of VEGF mRNA and protein expression were also downregulated following FOXM1 silencing. FOXM1 may therefore promote the development of preeclampsia via the VEGF signaling pathway.
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July-2018
Volume 16 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Cui X, Xu J, Ji Y, Song X, Wang J, Zhang L, Yang S and Ye Y: Effects of forkhead box protein M1 on trophoblast invasion and its role in preeclampsia development. Exp Ther Med 16: 197-203, 2018
APA
Cui, X., Xu, J., Ji, Y., Song, X., Wang, J., Zhang, L. ... Ye, Y. (2018). Effects of forkhead box protein M1 on trophoblast invasion and its role in preeclampsia development. Experimental and Therapeutic Medicine, 16, 197-203. https://doi.org/10.3892/etm.2018.6195
MLA
Cui, X., Xu, J., Ji, Y., Song, X., Wang, J., Zhang, L., Yang, S., Ye, Y."Effects of forkhead box protein M1 on trophoblast invasion and its role in preeclampsia development". Experimental and Therapeutic Medicine 16.1 (2018): 197-203.
Chicago
Cui, X., Xu, J., Ji, Y., Song, X., Wang, J., Zhang, L., Yang, S., Ye, Y."Effects of forkhead box protein M1 on trophoblast invasion and its role in preeclampsia development". Experimental and Therapeutic Medicine 16, no. 1 (2018): 197-203. https://doi.org/10.3892/etm.2018.6195