Insulin‑like growth factor 1/insulin‑like growth factor 1 receptor signaling protects against cell apoptosis through the PI3K/AKT pathway in glioblastoma cells

  • Authors:
    • Mingshi Zhang
    • Jinrui Liu
    • Mingjun Li
    • Shihua Zhang
    • Yanmei Lu
    • Yanqiu Liang
    • Kai Zhao
    • Yingfu Li
  • View Affiliations

  • Published online on: June 21, 2018     https://doi.org/10.3892/etm.2018.6336
  • Pages: 1477-1482
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Glioblastoma multiforme (GBM) is a malignant tumor caused by complex pathological mechanisms, and is characterized by a high rate of cancer‑related mortality and poor patient prognosis. Overgrowth of cancer cells, which results from the inhibition of cell apoptosis and/or the promotion of cell proliferation, leads to the progression of GBM. Therefore, studies into the regulatory mechanisms of cancer cell growth in GBM are required to identify potential therapeutic targets and improve treatment for GBM. In the present study, the role of insulin‑like growth factor 1 (IGF1)/IGF1 receptor (IGF1R) signaling in the survival of GBM cells was evaluated. It was observed that IGF1 significantly inhibited the intrinsic and extrinsic pathways of apoptosis (P<0.05), and overexpression of IGF1R significantly promoted the survival of GBM cells (P<0.05). Moreover, both exogenous IGF1 and overexpression of IGF1R promoted the phosphorylation of protein kinase B (AKT), and inhibition of the phosphoinositide 3‑kinase (PI3K)/AKT pathway significantly attenuated the inhibitory effects of IGF1/IGF1R on GBM apoptosis (P<0.05). Collectively, these findings indicate that IGF1/IGF1R promotes the survival of GBM cells through activation of the PI3K/AKT pathway. Therefore, inhibition of IGF1/IGF1R may be a viable therapeutic strategy to suppress the progression of GBM.
View Figures
View References

Related Articles

Journal Cover

August-2018
Volume 16 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhang M, Liu J, Li M, Zhang S, Lu Y, Liang Y, Zhao K and Li Y: Insulin‑like growth factor 1/insulin‑like growth factor 1 receptor signaling protects against cell apoptosis through the PI3K/AKT pathway in glioblastoma cells. Exp Ther Med 16: 1477-1482, 2018
APA
Zhang, M., Liu, J., Li, M., Zhang, S., Lu, Y., Liang, Y. ... Li, Y. (2018). Insulin‑like growth factor 1/insulin‑like growth factor 1 receptor signaling protects against cell apoptosis through the PI3K/AKT pathway in glioblastoma cells. Experimental and Therapeutic Medicine, 16, 1477-1482. https://doi.org/10.3892/etm.2018.6336
MLA
Zhang, M., Liu, J., Li, M., Zhang, S., Lu, Y., Liang, Y., Zhao, K., Li, Y."Insulin‑like growth factor 1/insulin‑like growth factor 1 receptor signaling protects against cell apoptosis through the PI3K/AKT pathway in glioblastoma cells". Experimental and Therapeutic Medicine 16.2 (2018): 1477-1482.
Chicago
Zhang, M., Liu, J., Li, M., Zhang, S., Lu, Y., Liang, Y., Zhao, K., Li, Y."Insulin‑like growth factor 1/insulin‑like growth factor 1 receptor signaling protects against cell apoptosis through the PI3K/AKT pathway in glioblastoma cells". Experimental and Therapeutic Medicine 16, no. 2 (2018): 1477-1482. https://doi.org/10.3892/etm.2018.6336