Open Access

Clinical significance of optical coherence tomography‑guided angioplasty on treatment selection

  • Authors:
    • Jianfeng Huang
    • Kamal Belmadani
    • Marion Chatot
    • Fiona Ecarnot
    • Romain Chopard
    • Manhong Wang
    • Xu Cai
    • Francois Schiele
    • Nicolas Meneveau
  • View Affiliations

  • Published online on: May 30, 2018     https://doi.org/10.3892/etm.2018.6237
  • Pages: 483-492
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to observe whether optical coherence tomography (OCT)-guided angioplasty is able to provide useful clinical information beyond that obtained by angiography as well as provide recommendations for physicians that may improve treatment selection. This prospective study included 83 patients with coronary artery disease (>18 years) undergoing coronary angiography (CAG) for ST‑elevation myocardial infarction (n=13), non‑ST‑elevation myocardial infarction (n=19), stable angina (n=22), unstable angina (n=10), silent ischemia (n=11), or elective percutaneous coronary intervention (n=8). Following the initial CAG (CAG‑pre), the patients underwent OCT before angioplasty (OCT‑pre, 24 patients), after angioplasty (OCT‑post, 22 patients), or both (37 patients). The thrombus burden, calcification and plaque dissection or rupture were compared between the OCT‑pre and CAG‑pre recordings. Following angioplasty, stent malapposition, suboptimal stent deployment, suboptimal stent lesion coverage, and edge dissection were compared between OCT‑post and CAG‑post alone. Among the 83 patients, 45.7% had single‑vessel and 54.3% had multiple‑vessel disease. OCT pre‑ and post‑angioplasty revealed significantly more information on the procedure than CAG alone. This clinical information changed the clinical strategies in 41/83 (49.4%) patients, including 58 modifications of therapeutic strategy (69.9%, 58/83): Thrombus aspiration in 2 cases (2.4%), administration of glycoprotein IIb/IIIa inhibitors in 8 cases (9.6%), additional balloon inflation in 23 cases (27.7%), additional stent implantation in 17 cases (20.5%), avoiding stent implantation in 4 cases (4.8%), collateral intervention in 2 cases (2.4%), and guidewire reposition in 2 cases (2.4%). In conclusion, OCT‑pre and OCT‑post provided additional clinical information beyond that obtained by angiography alone, which resulted in modification of the treatment strategies in half of the included patients.
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August-2018
Volume 16 Issue 2

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Copy and paste a formatted citation
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Spandidos Publications style
Huang J, Belmadani K, Chatot M, Ecarnot F, Chopard R, Wang M, Cai X, Schiele F and Meneveau N: Clinical significance of optical coherence tomography‑guided angioplasty on treatment selection. Exp Ther Med 16: 483-492, 2018
APA
Huang, J., Belmadani, K., Chatot, M., Ecarnot, F., Chopard, R., Wang, M. ... Meneveau, N. (2018). Clinical significance of optical coherence tomography‑guided angioplasty on treatment selection. Experimental and Therapeutic Medicine, 16, 483-492. https://doi.org/10.3892/etm.2018.6237
MLA
Huang, J., Belmadani, K., Chatot, M., Ecarnot, F., Chopard, R., Wang, M., Cai, X., Schiele, F., Meneveau, N."Clinical significance of optical coherence tomography‑guided angioplasty on treatment selection". Experimental and Therapeutic Medicine 16.2 (2018): 483-492.
Chicago
Huang, J., Belmadani, K., Chatot, M., Ecarnot, F., Chopard, R., Wang, M., Cai, X., Schiele, F., Meneveau, N."Clinical significance of optical coherence tomography‑guided angioplasty on treatment selection". Experimental and Therapeutic Medicine 16, no. 2 (2018): 483-492. https://doi.org/10.3892/etm.2018.6237