Open Access

Intra‑articular, single‑shot co‑injection of hyaluronic acid and corticosteroids in knee osteoarthritis: A randomized controlled trial

  • Authors:
    • Shan‑Zheng Wang
    • Dong‑Ying Wu
    • Qing Chang
    • Yu‑Dong Guo
    • Chen Wang
    • Wei‑Min Fan
  • View Affiliations

  • Published online on: June 29, 2018     https://doi.org/10.3892/etm.2018.6371
  • Pages: 1928-1934
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to investigate whether the co‑injection of hyaluronic acid (HA) and corticosteroids (CS) was superior to HA alone in the treatment of knee OA. A total of 120 participants with symptomatic knee OA were recruited and formed the intention‑to‑treat population for a 6‑month follow‑up. In the HA group, patients received a single‑shot injection of 4 ml HA. In the HA&CS group, patients received a co‑injection of 3 ml compound betamethasone solution and 4 ml HA. Visual analog scale (VAS), Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and knee flexion motion were assessed as primary outcomes. Patients in the HA&CS group exhibited better pain relief and knee function at the time points of week 1, month 1 and month 3 (P<0.05). For the last follow‑up at month 6, the values did not differ significantly between these two groups. Patients in both groups exhibited improvement in pain, knee function, and range of motion following injection. For the final follow‑up at month 6, the mean VAS score, WOMAC score and knee flexion motion were still superior to that prior to treatment, but the values did not differ significantly. The co‑injection of HA and CS provided a rapid improvement in pain relief, knee function, and range of motion, but did not differ significantly from that of HA alone in the long term effect.
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September-2018
Volume 16 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang SZ, Wu DY, Chang Q, Guo YD, Wang C and Fan WM: Intra‑articular, single‑shot co‑injection of hyaluronic acid and corticosteroids in knee osteoarthritis: A randomized controlled trial. Exp Ther Med 16: 1928-1934, 2018
APA
Wang, S., Wu, D., Chang, Q., Guo, Y., Wang, C., & Fan, W. (2018). Intra‑articular, single‑shot co‑injection of hyaluronic acid and corticosteroids in knee osteoarthritis: A randomized controlled trial. Experimental and Therapeutic Medicine, 16, 1928-1934. https://doi.org/10.3892/etm.2018.6371
MLA
Wang, S., Wu, D., Chang, Q., Guo, Y., Wang, C., Fan, W."Intra‑articular, single‑shot co‑injection of hyaluronic acid and corticosteroids in knee osteoarthritis: A randomized controlled trial". Experimental and Therapeutic Medicine 16.3 (2018): 1928-1934.
Chicago
Wang, S., Wu, D., Chang, Q., Guo, Y., Wang, C., Fan, W."Intra‑articular, single‑shot co‑injection of hyaluronic acid and corticosteroids in knee osteoarthritis: A randomized controlled trial". Experimental and Therapeutic Medicine 16, no. 3 (2018): 1928-1934. https://doi.org/10.3892/etm.2018.6371