Echinocandins for Pneumocystis jirovecii pneumonia in non‑HIV patients: A case report

  • Authors:
    • Hui‑Bin Huang
    • Jing‑Min Peng
    • Bin Du
  • View Affiliations

  • Published online on: August 7, 2018     https://doi.org/10.3892/etm.2018.6587
  • Pages: 3227-3232
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Abstract

For the past two decades, echinocandins have shown prophylactic and therapeutic efficacy in patients with Pneumocystis jirovecii pneumonia (PJP), due to their ability to inhibit the synthesis of β‑1, 3‑glucan, a major component of the cell wall of P. jirovecii. The present study reported two cases of human immunodeficiency virus (HIV)‑negative patients who received echinocandins as a salvage therapy at Peking Union Medical College Hospital (Beijing, China), both of whom exhibited good responses to treatment. In both cases, polymerase chain reaction of sputum or bronchoalveolar lavage specimens became negative following treatment. The present study also performed a literature search to identify non‑HIV patients with PJP who previously received echinocandins. The results of the present study suggested that echinocandins maybe promising therapeutic agents in the treatment of non‑HIV patients with PJP, particularly in combination with trimethoprim‑sulfamethoxazole. Therefore, the results warrant a randomized controlled trial.
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October-2018
Volume 16 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Huang HB, Peng JM and Du B: Echinocandins for Pneumocystis jirovecii pneumonia in non‑HIV patients: A case report. Exp Ther Med 16: 3227-3232, 2018
APA
Huang, H., Peng, J., & Du, B. (2018). Echinocandins for Pneumocystis jirovecii pneumonia in non‑HIV patients: A case report. Experimental and Therapeutic Medicine, 16, 3227-3232. https://doi.org/10.3892/etm.2018.6587
MLA
Huang, H., Peng, J., Du, B."Echinocandins for Pneumocystis jirovecii pneumonia in non‑HIV patients: A case report". Experimental and Therapeutic Medicine 16.4 (2018): 3227-3232.
Chicago
Huang, H., Peng, J., Du, B."Echinocandins for Pneumocystis jirovecii pneumonia in non‑HIV patients: A case report". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3227-3232. https://doi.org/10.3892/etm.2018.6587