Open Access

MicroRNA‑466 inhibits osteosarcoma cell proliferation and induces apoptosis by targeting CCND1

  • Authors:
    • Wei Cao
    • Le Fang
    • Siyong Teng
    • Hongwei Chen
    • Tiejun Liu
  • View Affiliations

  • Published online on: October 22, 2018     https://doi.org/10.3892/etm.2018.6888
  • Pages: 5117-5122
  • Copyright: © Cao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Emerging pieces of evidence indicate that microRNA‑466 (miR‑466) serves as a tumor suppressor in several human tumors, including colorectal cancer and prostate cancer. However, whether miR‑466 is involved in osteosarcoma (OS) progression remains largely unknown. The present study demonstrated that miR‑466 was significantly downregulated in OS tissues and cell lines. Furthermore, it was revealed that the expression of miR‑466 was negatively correlated with OS severity. Moreover, low miR‑466 expression in patients with OS predicted poor prognosis. Through functional experiments, miR‑466 overexpression significantly inhibited the proliferation and cell cycle of OS cells while inducing cellular apoptosis. In terms of mechanism, it was revealed that CCND1 was a target of miR‑466 in OS cells. miR‑466 overexpression suppressed CCND1 expression in OS cells. A reverse association was observed between the expression levels of miR‑466 and CCND1 in OS tissues. Furthermore, CCND1 restoration in OS cells significantly rescued the effects of miR‑466 on cellular proliferation and apoptosis. Overall, the results of the present study demonstrated that miR‑466 suppressed OS progression by targeting CCND1, suggesting that miR‑466 may be a promising biomarker and therapeutic target for OS prognosis and treatment.
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December-2018
Volume 16 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Cao W, Fang L, Teng S, Chen H and Liu T: MicroRNA‑466 inhibits osteosarcoma cell proliferation and induces apoptosis by targeting CCND1. Exp Ther Med 16: 5117-5122, 2018
APA
Cao, W., Fang, L., Teng, S., Chen, H., & Liu, T. (2018). MicroRNA‑466 inhibits osteosarcoma cell proliferation and induces apoptosis by targeting CCND1. Experimental and Therapeutic Medicine, 16, 5117-5122. https://doi.org/10.3892/etm.2018.6888
MLA
Cao, W., Fang, L., Teng, S., Chen, H., Liu, T."MicroRNA‑466 inhibits osteosarcoma cell proliferation and induces apoptosis by targeting CCND1". Experimental and Therapeutic Medicine 16.6 (2018): 5117-5122.
Chicago
Cao, W., Fang, L., Teng, S., Chen, H., Liu, T."MicroRNA‑466 inhibits osteosarcoma cell proliferation and induces apoptosis by targeting CCND1". Experimental and Therapeutic Medicine 16, no. 6 (2018): 5117-5122. https://doi.org/10.3892/etm.2018.6888