Open Access

Myricetin attenuates the severity of seizures and neuroapoptosis in pentylenetetrazole kindled mice by regulating the of BDNF‑TrkB signaling pathway and modulating matrix metalloproteinase‑9 and GABAA

  • Authors:
    • Zhi‑Qing Sun
    • Fan‑Hua Meng
    • Li‑Xiang Tu
    • Lei Sun
  • View Affiliations

  • Published online on: February 15, 2019     https://doi.org/10.3892/etm.2019.7282
  • Pages: 3083-3091
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Currently available antiepileptic drugs are effective; however, frequently associated with adverse effects that limit their therapeutic value. Compounds that target the molecular events underlying epilepsy, with minor or no adverse effects, would be of clinical value. Matrix metalloproteinase‑9 (MMP‑9) and the brain‑derived neurotrophic factor (BDNF)‑tropomyosin receptor kinase B (TrkB) signaling pathway may be involved in epileptogenesis. The current study investigated the effects of the plant‑derived hydroxyflavone, myricetin, in a pentylenetetrazole (PTZ)‑induced mouse model of epilepsy. Mice received an intraperitoneal injection of 35 mg/kg body weight PTZ on alternate days (13 injections) and were observed for 30 min following each PTZ injection. Myricetin (100 or 200 mg/kg body weight) was administered orally to the treatment groups (n=18/group) for 26 days, 30 min prior to each PTZ injection. Treatment with myricetin reduced seizure and mortality rates. Increased apoptotic cell count and elevated expression levels of apoptotic proteins caused by PTZ kindling were downregulated following treatment with myricetin. The BDNF‑TrkB signaling pathway and MMP‑9 expression levels were regulated by myricetin. Expression of γ‑aminobutyric acid A (GABA) receptor and glutamic acid decarboxylase 65, as well as the glutamate/GABA balance, were restored following treatment with myricetin. The results of the present study indicated that myricetin may exert protective effects by regulating the molecular events associated with epileptogenesis.
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April-2019
Volume 17 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Sun ZQ, Meng FH, Tu LX and Sun L: Myricetin attenuates the severity of seizures and neuroapoptosis in pentylenetetrazole kindled mice by regulating the of BDNF‑TrkB signaling pathway and modulating matrix metalloproteinase‑9 and GABAA. Exp Ther Med 17: 3083-3091, 2019
APA
Sun, Z., Meng, F., Tu, L., & Sun, L. (2019). Myricetin attenuates the severity of seizures and neuroapoptosis in pentylenetetrazole kindled mice by regulating the of BDNF‑TrkB signaling pathway and modulating matrix metalloproteinase‑9 and GABAA. Experimental and Therapeutic Medicine, 17, 3083-3091. https://doi.org/10.3892/etm.2019.7282
MLA
Sun, Z., Meng, F., Tu, L., Sun, L."Myricetin attenuates the severity of seizures and neuroapoptosis in pentylenetetrazole kindled mice by regulating the of BDNF‑TrkB signaling pathway and modulating matrix metalloproteinase‑9 and GABAA". Experimental and Therapeutic Medicine 17.4 (2019): 3083-3091.
Chicago
Sun, Z., Meng, F., Tu, L., Sun, L."Myricetin attenuates the severity of seizures and neuroapoptosis in pentylenetetrazole kindled mice by regulating the of BDNF‑TrkB signaling pathway and modulating matrix metalloproteinase‑9 and GABAA". Experimental and Therapeutic Medicine 17, no. 4 (2019): 3083-3091. https://doi.org/10.3892/etm.2019.7282