Association between EML4-ALK fusion gene and thymidylate synthase mRNA expression in non-small cell lung cancer tissues

  • Authors:
    • Chun‑Wei Xu
    • Gang Wang
    • Wu‑Long Wang
    • Wen‑Bin Gao
    • Chuan‑Jun Han
    • Jing‑Shan Gao
    • Li‑Ying Zhang
    • Yang Li
    • Lin Wang
    • Yu‑Ping Zhang
    • Yu‑Wang Tian
    • Dong‑Dong Qi
  • View Affiliations

  • Published online on: March 19, 2015     https://doi.org/10.3892/etm.2015.2372
  • Pages: 2151-2154
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Abstract

This study aimed to investigate the association of the mRNA expression of the echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion gene with that of thymidylate synthase (TYMS) in non‑small cell lung cancer (NSCLC) tissues. Quantitative polymerase chain reaction was used to detect the expression of EML4‑ALK fusion gene and TYMS mRNA in 257 cases of NSCLC. The positive rate of EML4‑ALK fusion gene was 4.28% in the NSCLC tissues (11/257), and was higher in nonsmokers than in smokers (P<0.05); TYMS mRNA expression was detected in 63.42% (163/257) of cases. An association of the EML4‑ALK fusion gene with TYMS expression was detected; a low expression level of TYMS mRNA was observed more frequently when the EML4‑ALK fusion gene was present than when it was not detected (P<0.05). In conclusion, patients positive for the EML4‑ALK fusion gene in NSCLC tissues are likely to have a low expression level of TYMS, and may benefit from the first‑line chemotherapy drug pemetrexed.
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June-2015
Volume 9 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Xu CW, Wang G, Wang WL, Gao WB, Han CJ, Gao JS, Zhang LY, Li Y, Wang L, Zhang YP, Zhang YP, et al: Association between EML4-ALK fusion gene and thymidylate synthase mRNA expression in non-small cell lung cancer tissues. Exp Ther Med 9: 2151-2154, 2015
APA
Xu, C., Wang, G., Wang, W., Gao, W., Han, C., Gao, J. ... Qi, D. (2015). Association between EML4-ALK fusion gene and thymidylate synthase mRNA expression in non-small cell lung cancer tissues. Experimental and Therapeutic Medicine, 9, 2151-2154. https://doi.org/10.3892/etm.2015.2372
MLA
Xu, C., Wang, G., Wang, W., Gao, W., Han, C., Gao, J., Zhang, L., Li, Y., Wang, L., Zhang, Y., Tian, Y., Qi, D."Association between EML4-ALK fusion gene and thymidylate synthase mRNA expression in non-small cell lung cancer tissues". Experimental and Therapeutic Medicine 9.6 (2015): 2151-2154.
Chicago
Xu, C., Wang, G., Wang, W., Gao, W., Han, C., Gao, J., Zhang, L., Li, Y., Wang, L., Zhang, Y., Tian, Y., Qi, D."Association between EML4-ALK fusion gene and thymidylate synthase mRNA expression in non-small cell lung cancer tissues". Experimental and Therapeutic Medicine 9, no. 6 (2015): 2151-2154. https://doi.org/10.3892/etm.2015.2372