Interactions between human embryonic forebrain cells and the cytokines interferon-gamma and interleukin-4.

  • Authors:
    • A Mousa
    • M Mustafa
    • A Kjaeldgaard
    • L Wahlberg
    • A Seiger
    • M Bakhiet
  • View Affiliations

  • Published online on: January 1, 1998     https://doi.org/10.3892/ijmm.1.1.171
  • Pages: 171-177
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Abstract

In the present study we investigated the capacity of human first trimester forebrain cells at different gestational ages to produce IFN-gamma and IL-4. We also studied the effects of IFN-gamma on their proliferation, survival and expression of MHC antigens. IFN-gamma but not IL-4 was spontaneously produced after 24 h cultures. Furthermore, IFN-gamma exhibited anti-proliferative effects and induced MHC expression on these cells. However, the IFN-gamma exposed cultures showed significantly higher cell survival compared to un-exposed cultures. Co-culture with IL-4 blocked the IFN-gamma production and reversed its anti-proliferative effects. These interactions suggest important roles for cytokines in the survival, proliferation and differentiation of human embryonic and fetal forebrain cells.

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Jan 1998
Volume 1 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Mousa A, Mustafa M, Kjaeldgaard A, Wahlberg L, Seiger A and Bakhiet M: Interactions between human embryonic forebrain cells and the cytokines interferon-gamma and interleukin-4.. Int J Mol Med 1: 171-177, 1998
APA
Mousa, A., Mustafa, M., Kjaeldgaard, A., Wahlberg, L., Seiger, A., & Bakhiet, M. (1998). Interactions between human embryonic forebrain cells and the cytokines interferon-gamma and interleukin-4.. International Journal of Molecular Medicine, 1, 171-177. https://doi.org/10.3892/ijmm.1.1.171
MLA
Mousa, A., Mustafa, M., Kjaeldgaard, A., Wahlberg, L., Seiger, A., Bakhiet, M."Interactions between human embryonic forebrain cells and the cytokines interferon-gamma and interleukin-4.". International Journal of Molecular Medicine 1.1 (1998): 171-177.
Chicago
Mousa, A., Mustafa, M., Kjaeldgaard, A., Wahlberg, L., Seiger, A., Bakhiet, M."Interactions between human embryonic forebrain cells and the cytokines interferon-gamma and interleukin-4.". International Journal of Molecular Medicine 1, no. 1 (1998): 171-177. https://doi.org/10.3892/ijmm.1.1.171