Reduction of platelet phospholipase C-delta1 activity in Alzheimer's disease associated with a specific apolipoprotein E genotype (epsilon3/epsilon3).

  • Authors:
    • H Matsushima
    • S Shimohama
    • J Kawamata
    • S Fujimoto
    • T Takenawa
    • J Kimura
  • View Affiliations

  • Published online on: January 1, 1998     https://doi.org/10.3892/ijmm.1.1.91
  • Pages: 91-94
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Abstract

The epsilon4 allele of apolipoprotein E (apo E) is increased among patients with sporadic or familial Alzheimer's disease (AD). We examined platelet phospholipase C (PLC)-delta1 activity in AD patients either homozygous for apoepsilon3 or having at least one apo epsilon4 allele. We found that platelet PLC-delta1 activity is reduced from control levels in patients homozygous for apo epsilon3, but not changed in patients with an apo epilson4 allele. Reduced PLC-delta1 activity and apo epsilon3 may contribute to AD pathogenesis apart from the apo epsilon4 allele.

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Jan 1998
Volume 1 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Matsushima H, Shimohama S, Kawamata J, Fujimoto S, Takenawa T and Kimura J: Reduction of platelet phospholipase C-delta1 activity in Alzheimer's disease associated with a specific apolipoprotein E genotype (epsilon3/epsilon3).. Int J Mol Med 1: 91-94, 1998
APA
Matsushima, H., Shimohama, S., Kawamata, J., Fujimoto, S., Takenawa, T., & Kimura, J. (1998). Reduction of platelet phospholipase C-delta1 activity in Alzheimer's disease associated with a specific apolipoprotein E genotype (epsilon3/epsilon3).. International Journal of Molecular Medicine, 1, 91-94. https://doi.org/10.3892/ijmm.1.1.91
MLA
Matsushima, H., Shimohama, S., Kawamata, J., Fujimoto, S., Takenawa, T., Kimura, J."Reduction of platelet phospholipase C-delta1 activity in Alzheimer's disease associated with a specific apolipoprotein E genotype (epsilon3/epsilon3).". International Journal of Molecular Medicine 1.1 (1998): 91-94.
Chicago
Matsushima, H., Shimohama, S., Kawamata, J., Fujimoto, S., Takenawa, T., Kimura, J."Reduction of platelet phospholipase C-delta1 activity in Alzheimer's disease associated with a specific apolipoprotein E genotype (epsilon3/epsilon3).". International Journal of Molecular Medicine 1, no. 1 (1998): 91-94. https://doi.org/10.3892/ijmm.1.1.91