Host H-2 haplotype modulates the induction of host-versus-graft disease after the induction of neonatal tolerance to H-2 alloantigens.

  • Authors:
    • A Ramos
    • M López-Hoyos
    • M Labrador
    • M González
    • J L Rodríguez-Sánchez
    • J Merino
  • View Affiliations

  • Published online on: February 1, 1998     https://doi.org/10.3892/ijmm.1.2.431
  • Pages: 431-438
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Mice injected at birth with semiallogeneic spleen cells develop a host-versus-graft disease (HVGD) characterized by the polyclonal activation of donor B cells by alloreactive host CD4+ T cells, the production of autoantibodies (autoAb) and the development of an inmmunocomplex-mediated glomerulonephritis. It has been demonstrated that the recognition of MHC class II, but not class I or non MHC, alloantigens triggers the development of the autoimmune syndrome (AIS). The finding of different expression patterns of Ia molecules in different mouse strains, and a closed restriction of some immune responses to particular H-2 haplotypes, prompted us to analyze whether variations in the expressed MHC class II molecules modify the HVGD. First, newborn BALB/c mice received spleen cells from F1 hybrid mice obtained by mating BALB/c mice with several mouse strains differing in the H-2 haplotype. Second, spleen cells from different F1 mice were neonatally injected in mice of both parental strains. All groups of BALB/c mice injected with different combinations of F1 mice showed an HVGD with a very similar serological course. However, in some instances, duration was different when comparing both parental strains injected with spleen cells from the mutual F1 hybrids. These results suggest that host MHC, but not donor MHC haplotype may modulate the AIS associated with the induction of neonatal tolerance.

Related Articles

Journal Cover

Feb 1998
Volume 1 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ramos A, López-Hoyos M, Labrador M, González M, Rodríguez-Sánchez J and Merino J: Host H-2 haplotype modulates the induction of host-versus-graft disease after the induction of neonatal tolerance to H-2 alloantigens.. Int J Mol Med 1: 431-438, 1998
APA
Ramos, A., López-Hoyos, M., Labrador, M., González, M., Rodríguez-Sánchez, J., & Merino, J. (1998). Host H-2 haplotype modulates the induction of host-versus-graft disease after the induction of neonatal tolerance to H-2 alloantigens.. International Journal of Molecular Medicine, 1, 431-438. https://doi.org/10.3892/ijmm.1.2.431
MLA
Ramos, A., López-Hoyos, M., Labrador, M., González, M., Rodríguez-Sánchez, J., Merino, J."Host H-2 haplotype modulates the induction of host-versus-graft disease after the induction of neonatal tolerance to H-2 alloantigens.". International Journal of Molecular Medicine 1.2 (1998): 431-438.
Chicago
Ramos, A., López-Hoyos, M., Labrador, M., González, M., Rodríguez-Sánchez, J., Merino, J."Host H-2 haplotype modulates the induction of host-versus-graft disease after the induction of neonatal tolerance to H-2 alloantigens.". International Journal of Molecular Medicine 1, no. 2 (1998): 431-438. https://doi.org/10.3892/ijmm.1.2.431