Anthracycline-derived chemotherapeutics in apoptosis and free radical cytotoxicity (Review).

  • Authors:
    • I Müller
    • D Niethammer
    • G Bruchelt
  • View Affiliations

  • Published online on: February 1, 1998     https://doi.org/10.3892/ijmm.1.2.491
  • Pages: 491-495
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Abstract

Anthracycline-derivatives are frequently used chemotherapeutics in treatment of numerous human malignancies. Anthracyclines are known for their complex cytotoxic mechanism involving i) inhibition of enzymes such as topoisomerase II, RNA polymerase, cytochrome c oxidase and others; ii) intercalation into DNA; iii) chelation of iron and generation of reactive oxygen species (ROS); iv) induction of apoptosis. Here, mechanistic aspects for successful cytostasis and for side effects, e.g. cardiomyopathy, are discussed. We emphasize recent developments in anthracycline-mediated apoptosis and focus on a well known representative, doxorubicin (adriamycin, adriblastin). We reflect on the role of oxidative stress and interactions with intracellular signaling pathways.

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Feb 1998
Volume 1 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Müller I, Niethammer D and Bruchelt G: Anthracycline-derived chemotherapeutics in apoptosis and free radical cytotoxicity (Review).. Int J Mol Med 1: 491-495, 1998
APA
Müller, I., Niethammer, D., & Bruchelt, G. (1998). Anthracycline-derived chemotherapeutics in apoptosis and free radical cytotoxicity (Review).. International Journal of Molecular Medicine, 1, 491-495. https://doi.org/10.3892/ijmm.1.2.491
MLA
Müller, I., Niethammer, D., Bruchelt, G."Anthracycline-derived chemotherapeutics in apoptosis and free radical cytotoxicity (Review).". International Journal of Molecular Medicine 1.2 (1998): 491-495.
Chicago
Müller, I., Niethammer, D., Bruchelt, G."Anthracycline-derived chemotherapeutics in apoptosis and free radical cytotoxicity (Review).". International Journal of Molecular Medicine 1, no. 2 (1998): 491-495. https://doi.org/10.3892/ijmm.1.2.491