Analysis of the DNA content in Bowen's disease.

  • Authors:
    • M Korabiowska
    • U Brinck
    • I Ruschenburg
    • S Kellner
    • M Droese
    • H Berger
  • View Affiliations

  • Published online on: March 1, 1998     https://doi.org/10.3892/ijmm.1.3.613
  • Pages: 613-619
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of this study was to evaluate the DNA content in Bowen's disease in comparison to healthy epidermis applying image cytophotometry. The material investigated was derived from 50 patients with Bowen's disease and 10 patients with healthy skin. For comparison of both groups the Kruskal-Wallis test was applied. Slides were stained with Feulgen and were evaluated with CAS-200 image analyzer. Only 7/50 morbus Bowen cases represented euploid histogram. The others 43/50 were either conspicious to be aneuploid (29/50) or clearly aneuploid (14/50). In contrast, all normal epidermis (10/10) were clearly euploid. Morbus Bowen cases demonstrated significantly higher 5c exceeding rate (p=0.0012) and significantly more cells in the S-phase (p=0.017). High aneuploidy rate and increased proliferative activity in morbus Bowen cases support the classification of these lesion as carcinoma in situ.

Related Articles

Journal Cover

Mar 1998
Volume 1 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Korabiowska M, Brinck U, Ruschenburg I, Kellner S, Droese M and Berger H: Analysis of the DNA content in Bowen's disease.. Int J Mol Med 1: 613-619, 1998
APA
Korabiowska, M., Brinck, U., Ruschenburg, I., Kellner, S., Droese, M., & Berger, H. (1998). Analysis of the DNA content in Bowen's disease.. International Journal of Molecular Medicine, 1, 613-619. https://doi.org/10.3892/ijmm.1.3.613
MLA
Korabiowska, M., Brinck, U., Ruschenburg, I., Kellner, S., Droese, M., Berger, H."Analysis of the DNA content in Bowen's disease.". International Journal of Molecular Medicine 1.3 (1998): 613-619.
Chicago
Korabiowska, M., Brinck, U., Ruschenburg, I., Kellner, S., Droese, M., Berger, H."Analysis of the DNA content in Bowen's disease.". International Journal of Molecular Medicine 1, no. 3 (1998): 613-619. https://doi.org/10.3892/ijmm.1.3.613