ATP in iron overload-induced intracellular calcium changes.

  • Authors:
    • L J Anghileri
    • P Thouvenot
  • View Affiliations

  • Published online on: May 1, 1998     https://doi.org/10.3892/ijmm.1.5.869
  • Pages: 869-942
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Abstract

The cellular iron uptake from low molecular weight iron complexes (ferric citrate, ferric lactate and ferric ATP complex) is concentration-dependent, and only a small part of the iron penetrates the cell as shown by deferoxamine treatment. A threshold of iron concentration in the cell must be reached for the iron complex-induced increase of cellular Ca2+-uptake. ATP seems to play a key role in an iron translocation that enhances the effects of the iron complexes. A non-specific and competitive iron-binding by proteins seems to act as a buffer system that reduces the iron overload effects. Calcium channel blockers have no effects on the iron complex-cell interaction or iron-induced Ca2+-uptake modification. An iron complex concentration-dependent inhibition of the CaATPase activity, and its consequent Ca2+-extrusion impairment appear as the likely cause of calcium overload. The relevance of these findings in iron overload-induced pathologies is discussed.

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May 1998
Volume 1 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Anghileri L and Anghileri L: ATP in iron overload-induced intracellular calcium changes.. Int J Mol Med 1: 869-942, 1998
APA
Anghileri, L., & Anghileri, L. (1998). ATP in iron overload-induced intracellular calcium changes.. International Journal of Molecular Medicine, 1, 869-942. https://doi.org/10.3892/ijmm.1.5.869
MLA
Anghileri, L., Thouvenot, P."ATP in iron overload-induced intracellular calcium changes.". International Journal of Molecular Medicine 1.5 (1998): 869-942.
Chicago
Anghileri, L., Thouvenot, P."ATP in iron overload-induced intracellular calcium changes.". International Journal of Molecular Medicine 1, no. 5 (1998): 869-942. https://doi.org/10.3892/ijmm.1.5.869