Correlation between interleukin 10 and vascular endothelial growth factor expression in human esophageal cancer

  • Authors:
    • Junko Nagata
    • Hiroshi Kijima
    • Hiroyuki Hatanaka
    • Tetsuji Tokunaga
    • Atsushi Takagi
    • Tetsuya Mine
    • Hitoshi Yamazaki
    • Masato Nakamura
    • Yoshito Ueyama
  • View Affiliations

  • Published online on: August 1, 2002     https://doi.org/10.3892/ijmm.10.2.169
  • Pages: 169-172
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Abstract

Interleukin 10 (IL-10) is an immunosuppressive cytokine produced by T-lymphocytes, and is a regulatory molecule for angiogenesis in various cancers. We examined IL-10 and vascular endothelial growth factor (VEGF) gene expression in 45 esophageal cancer patients who underwent surgical resection. Thirty-seven (82.2%) of the 45 esophageal cancers revealed IL-10 gene expression. VEGF121, VEGF165 and VEGF189 isoforms were detected in 93.3% (42/45), 55.6% (25/45) and 26.7% (12/45) of cases, respectively. IL-10 gene expression was significantly correlated with VEGF121 gene expression (P=0.0039, Fisher's test). The results suggested that IL-10 stimulates angiogenic factor gene expression.

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August 2002
Volume 10 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Nagata J, Kijima H, Hatanaka H, Tokunaga T, Takagi A, Mine T, Yamazaki H, Nakamura M and Ueyama Y: Correlation between interleukin 10 and vascular endothelial growth factor expression in human esophageal cancer. Int J Mol Med 10: 169-172, 2002
APA
Nagata, J., Kijima, H., Hatanaka, H., Tokunaga, T., Takagi, A., Mine, T. ... Ueyama, Y. (2002). Correlation between interleukin 10 and vascular endothelial growth factor expression in human esophageal cancer. International Journal of Molecular Medicine, 10, 169-172. https://doi.org/10.3892/ijmm.10.2.169
MLA
Nagata, J., Kijima, H., Hatanaka, H., Tokunaga, T., Takagi, A., Mine, T., Yamazaki, H., Nakamura, M., Ueyama, Y."Correlation between interleukin 10 and vascular endothelial growth factor expression in human esophageal cancer". International Journal of Molecular Medicine 10.2 (2002): 169-172.
Chicago
Nagata, J., Kijima, H., Hatanaka, H., Tokunaga, T., Takagi, A., Mine, T., Yamazaki, H., Nakamura, M., Ueyama, Y."Correlation between interleukin 10 and vascular endothelial growth factor expression in human esophageal cancer". International Journal of Molecular Medicine 10, no. 2 (2002): 169-172. https://doi.org/10.3892/ijmm.10.2.169