Angiopoietin-1 and vascular endothelial growth factor expression in human esophageal cancer

  • Authors:
    • Junko Nagata
    • Hiroshi Kijima
    • Hiroyuki Hatanaka
    • Tetsuji Tokunaga
    • Junichiro Kamochi
    • Yoshiyuki Abe
    • Atsushi Takagi
    • Tetsuya Mine
    • Hitoshi Yamazaki
    • Masato Nakamura
    • Yoshito Ueyama
  • View Affiliations

  • Published online on: October 1, 2002     https://doi.org/10.3892/ijmm.10.4.423
  • Pages: 423-426
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Abstract

Angiopoietin-1 (Ang-1) has been shown to act as an angiogenic promoter in embryonic angiogenesis by promoting vascular branching, pericyte recruitment and endothelial survival. Ang-1 expression has not been examined in human esophageal cancer. We examined Ang-1 and vascular endothelial growth factor (VEGF) gene expression in tumors from 45 esophageal cancer patients who underwent surgical resection. Forty (88.9%) of the 45 esophageal cancers revealed Ang-1 gene expression. VEGF121, VEGF165 and VEGF189 isoforms were detected in 93.3 (42/45), 55.6 (25/45) and 26.7% (12/45) of the cases, respectively. Ang-1 gene expression was significantly correlated with VEGF121 and VEGF165 gene expression (P=0.0289 and P=0.0127, respectively, Fisher's test). The results suggest that Ang-1 is associated with neovascularization in the cancer stroma through VEGF net-works in esophageal cancer.

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October 2002
Volume 10 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Nagata J, Kijima H, Hatanaka H, Tokunaga T, Kamochi J, Abe Y, Takagi A, Mine T, Yamazaki H, Nakamura M, Nakamura M, et al: Angiopoietin-1 and vascular endothelial growth factor expression in human esophageal cancer. Int J Mol Med 10: 423-426, 2002
APA
Nagata, J., Kijima, H., Hatanaka, H., Tokunaga, T., Kamochi, J., Abe, Y. ... Ueyama, Y. (2002). Angiopoietin-1 and vascular endothelial growth factor expression in human esophageal cancer. International Journal of Molecular Medicine, 10, 423-426. https://doi.org/10.3892/ijmm.10.4.423
MLA
Nagata, J., Kijima, H., Hatanaka, H., Tokunaga, T., Kamochi, J., Abe, Y., Takagi, A., Mine, T., Yamazaki, H., Nakamura, M., Ueyama, Y."Angiopoietin-1 and vascular endothelial growth factor expression in human esophageal cancer". International Journal of Molecular Medicine 10.4 (2002): 423-426.
Chicago
Nagata, J., Kijima, H., Hatanaka, H., Tokunaga, T., Kamochi, J., Abe, Y., Takagi, A., Mine, T., Yamazaki, H., Nakamura, M., Ueyama, Y."Angiopoietin-1 and vascular endothelial growth factor expression in human esophageal cancer". International Journal of Molecular Medicine 10, no. 4 (2002): 423-426. https://doi.org/10.3892/ijmm.10.4.423