Influence of allergen-specific immunotherapy on IL-4-dependent IL-12 production by monocytes

  • Authors:
    • Katarzyna Grzela
    • Tomasz Grzela
    • Maciej Lazarczyk
    • Grazyna Korczak-Kowalska
    • Piotr Wierzbicki
    • Anna Zawadzka-Krajewska
    • Jaroslaw Jozwiak
    • Piotr Skopinski
  • View Affiliations

  • Published online on: October 1, 2002     https://doi.org/10.3892/ijmm.10.4.481
  • Pages: 481-484
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Abstract

Allergen-specific immunotherapy (AIT) is an effective method of allergy treatment. Reduction of allergy symptoms followed by AIT presumably depends on modification of cytokine production, especially of IFN-γ and/or IL-4. Previously, we found that lower IL-12 production by allergic monocytes than in healthy control, could depend on higher IL-4 receptor α-chain (CD124) expression. Since IFN-γ production is stimulated by IL-12, which in turn is down-regulated by IL-4, the aim of study was to analyze the influence of AIT on the network of these cytokines. Moreover, we estimated the possible role of CD124 in that process. Patients (n=16) with grass pollen allergy were subjected to AIT with Allergovit for 5 to 6 weeks. The clinical examination and blood analyses were performed before and after AIT. Clinical improvement in course of AIT was rather weak, however, we found significant increase of mean IFN-γ production by PBMC. Although the increase of mean IL-12 production by monocytes following AIT was non-significant, we observed statistically significant decrease of monocyte sensitivity to IL-4 suppressed IL-12 production. Flow cytometry analysis revealed significant decrease of CD124 expression on monocytes after AIT. Despite unchanged mean IL-4 level the decrease of CD124 expression after AIT could explain the decreased monocyte sensitivity to IL-4 and its role in further IL-12 and IFN-γ tuning.

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October 2002
Volume 10 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Grzela K, Grzela T, Lazarczyk M, Korczak-Kowalska G, Wierzbicki P, Zawadzka-Krajewska A, Jozwiak J and Skopinski P: Influence of allergen-specific immunotherapy on IL-4-dependent IL-12 production by monocytes. Int J Mol Med 10: 481-484, 2002
APA
Grzela, K., Grzela, T., Lazarczyk, M., Korczak-Kowalska, G., Wierzbicki, P., Zawadzka-Krajewska, A. ... Skopinski, P. (2002). Influence of allergen-specific immunotherapy on IL-4-dependent IL-12 production by monocytes. International Journal of Molecular Medicine, 10, 481-484. https://doi.org/10.3892/ijmm.10.4.481
MLA
Grzela, K., Grzela, T., Lazarczyk, M., Korczak-Kowalska, G., Wierzbicki, P., Zawadzka-Krajewska, A., Jozwiak, J., Skopinski, P."Influence of allergen-specific immunotherapy on IL-4-dependent IL-12 production by monocytes". International Journal of Molecular Medicine 10.4 (2002): 481-484.
Chicago
Grzela, K., Grzela, T., Lazarczyk, M., Korczak-Kowalska, G., Wierzbicki, P., Zawadzka-Krajewska, A., Jozwiak, J., Skopinski, P."Influence of allergen-specific immunotherapy on IL-4-dependent IL-12 production by monocytes". International Journal of Molecular Medicine 10, no. 4 (2002): 481-484. https://doi.org/10.3892/ijmm.10.4.481