Diol- and triol-types of phytol induce apoptosis in lymphoid leukemia Molt 4B cells

  • Authors:
    • H. Hibasami
    • M. Kyohkon
    • S. Owaki
    • H. Katsuzaki
    • K. Imai
    • K. Ohnishi
    • K. Ina
    • T. Komiya
  • View Affiliations

  • Published online on: November 1, 2002     https://doi.org/10.3892/ijmm.10.5.555
  • Pages: 555-559
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Abstract

The exposure of human lymphoid leukemia Molt 4B cells to diol- and triol-types of phytol which were synthesized and identified by Mass, and 1H- and 13C-NMR, led to both growth inhibition and induction of programmed cell death (apoptosis). Morphological changes showing apoptotic bodies were observed in the Molt 4B cells treated with diol- and triol-types of phytol. The fragmentations of DNA by the diol- and triol-types of pytol to oligonucleosomal-sized fragments, that is a characteristic of apoptosis, were observed to be both concentration- and time-dependent. These findings suggest that growth inhibition of Molt 4B cells by the diol- and triol-types of phytol results from the induction of apoptosis in the leukemic cells.

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November 2002
Volume 10 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Hibasami H, Kyohkon M, Owaki S, Katsuzaki H, Imai K, Ohnishi K, Ina K and Komiya T: Diol- and triol-types of phytol induce apoptosis in lymphoid leukemia Molt 4B cells. Int J Mol Med 10: 555-559, 2002
APA
Hibasami, H., Kyohkon, M., Owaki, S., Katsuzaki, H., Imai, K., Ohnishi, K. ... Komiya, T. (2002). Diol- and triol-types of phytol induce apoptosis in lymphoid leukemia Molt 4B cells. International Journal of Molecular Medicine, 10, 555-559. https://doi.org/10.3892/ijmm.10.5.555
MLA
Hibasami, H., Kyohkon, M., Owaki, S., Katsuzaki, H., Imai, K., Ohnishi, K., Ina, K., Komiya, T."Diol- and triol-types of phytol induce apoptosis in lymphoid leukemia Molt 4B cells". International Journal of Molecular Medicine 10.5 (2002): 555-559.
Chicago
Hibasami, H., Kyohkon, M., Owaki, S., Katsuzaki, H., Imai, K., Ohnishi, K., Ina, K., Komiya, T."Diol- and triol-types of phytol induce apoptosis in lymphoid leukemia Molt 4B cells". International Journal of Molecular Medicine 10, no. 5 (2002): 555-559. https://doi.org/10.3892/ijmm.10.5.555