Evaluation of telomerase in the development and progression of colon cancer

  • Authors:
    • L. Boldrini
    • P. Faviana
    • S. Gisfredi
    • Y. Zucconi
    • D. Di Quirico
    • V. Donati
    • P. Berti
    • R. Spisni
    • D. Galleri
    • G. Materazzi
    • F. Basolo
    • P. Miccoli
    • R. Pingitore
    • G. Fontanini
  • View Affiliations

  • Published online on: November 1, 2002     https://doi.org/10.3892/ijmm.10.5.589
  • Pages: 589-592
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Abstract

Telomerase activity, a cardinal requirement for immortalization, is a crucial step in the development of cancer and has been studied in many kinds of malignant tumours for clinical diagnostic and/or prognostic utilities. Using a PCR-based TRAP assay, we investigated telomerase activity in 8 adenomatous polyps, 9 dysplastic polyps, and in 36 paired cancer-normal mucosa specimens, one liver and one spleen metastasis from patients resected for sporadic colorectal cancer. Telomerase was absent or very low in normal mucosa and in adenomatous polyps. Dysplastic polyps and adenocarcinoma samples showed telomerase activity, with higher levels in cancer tissues compared to dysplastic lesions. A high telomerase activity was shown to be associated with late-staged cancers and metastasis, providing arguments supporting the role of telomerase not only in the development but also in the progression of colorectal carcinoma. Moreover, telomerase evaluation may help to confirm the malignant transformation in polypoid colorectal lesions with different levels of dysplastic alterations.

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November 2002
Volume 10 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Boldrini L, Faviana P, Gisfredi S, Zucconi Y, Di Quirico D, Donati V, Berti P, Spisni R, Galleri D, Materazzi G, Materazzi G, et al: Evaluation of telomerase in the development and progression of colon cancer. Int J Mol Med 10: 589-592, 2002
APA
Boldrini, L., Faviana, P., Gisfredi, S., Zucconi, Y., Di Quirico, D., Donati, V. ... Fontanini, G. (2002). Evaluation of telomerase in the development and progression of colon cancer. International Journal of Molecular Medicine, 10, 589-592. https://doi.org/10.3892/ijmm.10.5.589
MLA
Boldrini, L., Faviana, P., Gisfredi, S., Zucconi, Y., Di Quirico, D., Donati, V., Berti, P., Spisni, R., Galleri, D., Materazzi, G., Basolo, F., Miccoli, P., Pingitore, R., Fontanini, G."Evaluation of telomerase in the development and progression of colon cancer". International Journal of Molecular Medicine 10.5 (2002): 589-592.
Chicago
Boldrini, L., Faviana, P., Gisfredi, S., Zucconi, Y., Di Quirico, D., Donati, V., Berti, P., Spisni, R., Galleri, D., Materazzi, G., Basolo, F., Miccoli, P., Pingitore, R., Fontanini, G."Evaluation of telomerase in the development and progression of colon cancer". International Journal of Molecular Medicine 10, no. 5 (2002): 589-592. https://doi.org/10.3892/ijmm.10.5.589