Sulfotransferase 1A2*2 is a risk factor for early-onset breast cancer

  • Authors:
    • Ming-Feng Hou
    • Shou-Tung Chen
    • Jui-Chang Chen
    • Kun-Tu Yeh
    • Tai-Ping Lee
    • Chih-Mei Chen
    • Mu-Chin Shih
    • Cheng-Chieh Lin
    • Jan-Gowth Chang
  • View Affiliations

  • Published online on: November 1, 2002     https://doi.org/10.3892/ijmm.10.5.609
  • Pages: 609-612
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The estrogen-signaling pathway plays an important role in the pathophysiology of breast cancer, and the sulfotransferase 1A (SULT1A) family has been found to be both downstream targets of tamoxifen and a risk factor of breast cancer. We have used PCR-RFLP and direct sequencing methods to determine SULT1A2 polymorphisms in 230 Taiwanese breast cancer patients. The results showed that the frequencies of SULT1A2*1 and SULT1A2*2 occurring were 94.8% and 5.2%, respectively. No SULT1A2*3 allele was found in these patients. In comparison with the frequency of healthy controls (96.0% and 4.0% for SULT1A2*1 and SULT1A2*2, respectively), the allelic frequencies of SULT1A2 polymorphisms in these patients were not statistically significant (p=0.398). However, the SULT1A2*2 allele seems to influence the age of onset among early-onset breast cancer patients (p=0.021, OR=2.74, 95%CI=1.13-6.65).

Related Articles

Journal Cover

November 2002
Volume 10 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Hou M, Chen S, Chen J, Yeh K, Lee T, Chen C, Shih M, Lin C and Chang J: Sulfotransferase 1A2*2 is a risk factor for early-onset breast cancer. Int J Mol Med 10: 609-612, 2002
APA
Hou, M., Chen, S., Chen, J., Yeh, K., Lee, T., Chen, C. ... Chang, J. (2002). Sulfotransferase 1A2*2 is a risk factor for early-onset breast cancer. International Journal of Molecular Medicine, 10, 609-612. https://doi.org/10.3892/ijmm.10.5.609
MLA
Hou, M., Chen, S., Chen, J., Yeh, K., Lee, T., Chen, C., Shih, M., Lin, C., Chang, J."Sulfotransferase 1A2*2 is a risk factor for early-onset breast cancer". International Journal of Molecular Medicine 10.5 (2002): 609-612.
Chicago
Hou, M., Chen, S., Chen, J., Yeh, K., Lee, T., Chen, C., Shih, M., Lin, C., Chang, J."Sulfotransferase 1A2*2 is a risk factor for early-onset breast cancer". International Journal of Molecular Medicine 10, no. 5 (2002): 609-612. https://doi.org/10.3892/ijmm.10.5.609