MEN 2A families: from hot spots to hot regions

  • Authors:
    • M. J. Bugalho
    • R. Domingues
    • L. Sobrinho
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  • Published online on: January 1, 2003     https://doi.org/10.3892/ijmm.11.1.71
  • Pages: 71-74
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Abstract

The aim of this study was to look for common ancestors among MEN 2A Portuguese families presenting with the same germ-line mutation of the RET proto-oncogene. To address this question from a genetic point of view, we performed haplotype analysis in six out of nine, apparently separate, MEN 2A families using four polymorphic markers. Three families carrying the C634R mutation and presenting the same phenotype shared the same haplotype surrounding the MEN 2A mutation. Moreover, these families were originally from the same geographic region although settled at different places along the country. Altogether, data suggested a common ancestral MEN 2A chromosome for three families. Since MEN 2A is a rare inherited cancer syndrome, identification of common ancestors may draw attention for specific geographic regions from where other affected families may arise at a higher chance and, therefore, termed ‘hot regions’.

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January 2003
Volume 11 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Bugalho MJ, Domingues R and Sobrinho L: MEN 2A families: from hot spots to hot regions. Int J Mol Med 11: 71-74, 2003
APA
Bugalho, M.J., Domingues, R., & Sobrinho, L. (2003). MEN 2A families: from hot spots to hot regions. International Journal of Molecular Medicine, 11, 71-74. https://doi.org/10.3892/ijmm.11.1.71
MLA
Bugalho, M. J., Domingues, R., Sobrinho, L."MEN 2A families: from hot spots to hot regions". International Journal of Molecular Medicine 11.1 (2003): 71-74.
Chicago
Bugalho, M. J., Domingues, R., Sobrinho, L."MEN 2A families: from hot spots to hot regions". International Journal of Molecular Medicine 11, no. 1 (2003): 71-74. https://doi.org/10.3892/ijmm.11.1.71