Renin mRNA expression and renal dysfunction in tacrolimus-induced acute nephrotoxicity

  • Authors:
    • Tatsuya Nakatani
    • Junji Uchida
    • Tomoaki Iwai
    • Kentaro Matsumura
    • Toshihide Naganuma
    • Katsuyuki Kuratsukuri
    • Kazunobu Sugimura
  • View Affiliations

  • Published online on: January 1, 2003     https://doi.org/10.3892/ijmm.11.1.75
  • Pages: 75-78
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Abstract

Tacrolimus is a superior immunosuppressive agent and has markedly improved the short-term outcome of renal allografts. Despite the beneficial effects of maintaining immunotolerance in organ transplant recipients, it has well-characterized side effects on renal hemodynamics in the early phase. The mechanism of tacrolimus-induced acute nephrotoxicity is still unclear. The purpose of this study was to elucidate the role of renin-angiotensin system (RAS) in tacrolimus-induced acute nephrotoxicity. We examined the renal mRNA levels of renin in order to elucidate the relationship between plasma renin activity (PRA) and tacrolimus-induced renal dysfunction. Daily administration of tacrolimus (4 mg/kg/day) for 2 weeks in spontaneously hypertensive rats (SHR) significantly increased BUN and plasma creatinine (P-Cr) level, while endogenous creatinine clearance (Ccr) significantly decreased in tacrolimus treated rats. Regarding tubular function data, fractional excretion of Na (FENa) and fractional excretion of K were higher in the tacrolimus treated group. Renin mRNA levels in the renal cortex in tacrolimus treated rats significantly increased when compared to the vehicle-treated rats. Ccr level was inversely proportional to PRA, with a high correlation coeffecient. The rise in PRA significantly correlated with increase in FENa by liner regression. Therefore, the results indicate that RAS is involved in the tacrolimus-induced acute nephrotoxicity.

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January 2003
Volume 11 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Nakatani T, Uchida J, Iwai T, Matsumura K, Naganuma T, Kuratsukuri K and Sugimura K: Renin mRNA expression and renal dysfunction in tacrolimus-induced acute nephrotoxicity. Int J Mol Med 11: 75-78, 2003
APA
Nakatani, T., Uchida, J., Iwai, T., Matsumura, K., Naganuma, T., Kuratsukuri, K., & Sugimura, K. (2003). Renin mRNA expression and renal dysfunction in tacrolimus-induced acute nephrotoxicity. International Journal of Molecular Medicine, 11, 75-78. https://doi.org/10.3892/ijmm.11.1.75
MLA
Nakatani, T., Uchida, J., Iwai, T., Matsumura, K., Naganuma, T., Kuratsukuri, K., Sugimura, K."Renin mRNA expression and renal dysfunction in tacrolimus-induced acute nephrotoxicity". International Journal of Molecular Medicine 11.1 (2003): 75-78.
Chicago
Nakatani, T., Uchida, J., Iwai, T., Matsumura, K., Naganuma, T., Kuratsukuri, K., Sugimura, K."Renin mRNA expression and renal dysfunction in tacrolimus-induced acute nephrotoxicity". International Journal of Molecular Medicine 11, no. 1 (2003): 75-78. https://doi.org/10.3892/ijmm.11.1.75