Excision repair cross complementing-group 1: Gene expression and platinum resistance (Review) parameters in human breast cancer

  • Authors:
    • Ramin Altaha
    • Xiaobing Liang
    • Jing Jie Yu
    • Eddie Reed
  • View Affiliations

  • Published online on: December 1, 2004     https://doi.org/10.3892/ijmm.14.6.959
  • Pages: 959-970
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Abstract

Platinum compounds induce their cytotoxic effect by binding to a DNA molecule in the form of a platinum-DNA-adduct. Many previous studies have shown that the level of platinum-DNA-adduct correlats with response to platinum-based chemotherapy. Although the mechanism of platinum resistance in vivo is not clearly understood, laboratory studies on cancer cell lines suggest that nucleotide excision repair (NER) is the main mechanism responsible for this resistance by increased platinum-DNA-adduct removal. NER pathway is a network of many proteins gathered in a DNA-repair system. The excision repair cross complementing-group 1 (ERCC1) gene has the leading role in NER-pathway because of its damage recognition and excision ability. In this report we reviewed the pathway leading to ERCC1 gene transcription and translation in cancer cells when exposed to cisplatin. We summarized data from different cancer cell lines and human cancers showing that the high level of ERCC1-mRNA and/or ERCC1 protein is associated with resistance to platinum compounds with direct impact on cancer patient survival and finally we analyzed drugs interfering with ERCC1 gene expression and causing the reversal of the platinum resistance when given to cancer cells prior to platinum-based chemotherapy.

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December 2004
Volume 14 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Altaha R, Liang X, Yu JJ and Reed E: Excision repair cross complementing-group 1: Gene expression and platinum resistance (Review) parameters in human breast cancer. Int J Mol Med 14: 959-970, 2004
APA
Altaha, R., Liang, X., Yu, J.J., & Reed, E. (2004). Excision repair cross complementing-group 1: Gene expression and platinum resistance (Review) parameters in human breast cancer. International Journal of Molecular Medicine, 14, 959-970. https://doi.org/10.3892/ijmm.14.6.959
MLA
Altaha, R., Liang, X., Yu, J. J., Reed, E."Excision repair cross complementing-group 1: Gene expression and platinum resistance (Review) parameters in human breast cancer". International Journal of Molecular Medicine 14.6 (2004): 959-970.
Chicago
Altaha, R., Liang, X., Yu, J. J., Reed, E."Excision repair cross complementing-group 1: Gene expression and platinum resistance (Review) parameters in human breast cancer". International Journal of Molecular Medicine 14, no. 6 (2004): 959-970. https://doi.org/10.3892/ijmm.14.6.959