Quantitative and qualitative alterations of intestinal mucins in BioBreeding rats

  • Authors:
    • Philippe Courtois
    • Cedric Jurysta
    • Abdullah Sener
    • Fraser W. Scott
    • Willy J. Malaisse
  • View Affiliations

  • Published online on: January 1, 2005     https://doi.org/10.3892/ijmm.15.1.105
  • Pages: 105-108
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Abstract

In diabetes-prone BioBreeding rats, an enteropathy often precedes the onset of auto-immune insulitis. The present study draws attention to quantitative and qualitative alterations of intestinal mucins in this animal model of type 1 diabetes mellitus. Male and female diabetes-resistant (BBc) and diabetes-prone (BBdp) BioBreeding rats fed, from one to two weeks after weaning onwards, either a plant-based diabetes-promoting diet (NTP) or a hydrolysed casein diabetes-protective diet (HC), were sacrificed at 11-14 weeks of age. Proteins and total mucins, as well as acid and neutral mucins, were measured in a segment of the intestinal tract, located 25-30 cm below the pylorus. No significant difference between BBc and BBdp rats was found when fed the HC diet. However, the NTP diet lowered both total and neutral mucins, whilst failing to affect significantly acidic mucins. The effects of the NTP diet were more pronounced in BBdp rats than in BBc rats. It is speculated that the quantitative and qualitative changes evoked by the NTP diet in BBdp rats may play a role in the alteration of gut permeability found under the same experimental conditions.

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January 2005
Volume 15 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Courtois P, Jurysta C, Sener A, Scott FW and Malaisse WJ: Quantitative and qualitative alterations of intestinal mucins in BioBreeding rats. Int J Mol Med 15: 105-108, 2005
APA
Courtois, P., Jurysta, C., Sener, A., Scott, F.W., & Malaisse, W.J. (2005). Quantitative and qualitative alterations of intestinal mucins in BioBreeding rats. International Journal of Molecular Medicine, 15, 105-108. https://doi.org/10.3892/ijmm.15.1.105
MLA
Courtois, P., Jurysta, C., Sener, A., Scott, F. W., Malaisse, W. J."Quantitative and qualitative alterations of intestinal mucins in BioBreeding rats". International Journal of Molecular Medicine 15.1 (2005): 105-108.
Chicago
Courtois, P., Jurysta, C., Sener, A., Scott, F. W., Malaisse, W. J."Quantitative and qualitative alterations of intestinal mucins in BioBreeding rats". International Journal of Molecular Medicine 15, no. 1 (2005): 105-108. https://doi.org/10.3892/ijmm.15.1.105