Expression of hepatocyte growth factor and its receptor c-met, correlates with severity of pathological injury in experimental alcoholic liver disease

  • Authors:
    • El-Nasir Lalani
    • Richard Poulsom
    • Gordon Stamp
    • Franz Fogt
    • Peter Thomas
    • Amin A. Nanji
  • View Affiliations

  • Published online on: May 1, 2005     https://doi.org/10.3892/ijmm.15.5.811
  • Pages: 811-817
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Abstract

Expression of hepatocyte growth factor (HGF) and its receptor, c-met is up-regulated in various forms of liver injury. This study evaluated the relationship between HGF and c-met expression and pathological changes in experimental alcoholic liver disease. Rats (5 per group) were fed ethanol and a diet containing saturated fat corn oil or fish oil by intragastric infusion. Dextrose isocalorically replaced ethanol in controls. In a second set of experiments, Kupffer cells, endothelial cells and hepatocytes were isolated from rats in each group. Pathological evaluation and analysis of HGF and c-met expression were performed in liver and the different cell types. Increased expression of HGF and c-met expression was detected in the liver of rats showing necroinflammatory changes. The Kupffer and endothelial cells were primarily responsible for the increase in HGF, c-met expression was seen only in hepatocytes. Thus, up-regulation of HGF and c-met occurred in the presence of the necrosis and inflammation suggesting that HGF may be acting to protect against liver injury or accelerate the regenerative process.

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May 2005
Volume 15 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Lalani E, Poulsom R, Stamp G, Fogt F, Thomas P and Nanji AA: Expression of hepatocyte growth factor and its receptor c-met, correlates with severity of pathological injury in experimental alcoholic liver disease. Int J Mol Med 15: 811-817, 2005
APA
Lalani, E., Poulsom, R., Stamp, G., Fogt, F., Thomas, P., & Nanji, A.A. (2005). Expression of hepatocyte growth factor and its receptor c-met, correlates with severity of pathological injury in experimental alcoholic liver disease. International Journal of Molecular Medicine, 15, 811-817. https://doi.org/10.3892/ijmm.15.5.811
MLA
Lalani, E., Poulsom, R., Stamp, G., Fogt, F., Thomas, P., Nanji, A. A." Expression of hepatocyte growth factor and its receptor c-met, correlates with severity of pathological injury in experimental alcoholic liver disease". International Journal of Molecular Medicine 15.5 (2005): 811-817.
Chicago
Lalani, E., Poulsom, R., Stamp, G., Fogt, F., Thomas, P., Nanji, A. A." Expression of hepatocyte growth factor and its receptor c-met, correlates with severity of pathological injury in experimental alcoholic liver disease". International Journal of Molecular Medicine 15, no. 5 (2005): 811-817. https://doi.org/10.3892/ijmm.15.5.811