Intracerebroventricularly administered urocortin inhibits gastric emptying in mice

  • Authors:
    • Toshiaki Nagata
    • Masaharu Uemoto
    • Hideki Yuzuriha
    • Akihiro Asakawa
    • Akio Inui
    • Mineko Fujimiya
    • Ruka Sakamaki
    • Masato Kasuga
    • Naotaka Shinfuku
  • View Affiliations

  • Published online on: June 1, 2005     https://doi.org/10.3892/ijmm.15.6.1041
  • Pages: 1041-1043
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Abstract

Urocortin, a recently identified member of the corticotropin-releasing factor (CRF) family, is implicated in the central control of appetite and energy metabolism. We previously reported that peripherally administered urocortin inhibits gastric emptying in conscious mice. In this study, we investigated the effect of intracerebroventricularly administered urocortin on gastric emptying, food intake and body weight in mice. Urocortin decreased food intake and body weight gain more potently than CRF. It significantly decreased gastric emptying of a solid meal; an effect that was inhibited by simultaneous administration of α-helical CRF9-41, a CRF antagonist. These results suggest that the potent anorectic properties of urocortin may be partly due to the anti-gastroprokinetic activity of the peptide.

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June 2005
Volume 15 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Nagata T, Uemoto M, Yuzuriha H, Asakawa A, Inui A, Fujimiya M, Sakamaki R, Kasuga M and Shinfuku N: Intracerebroventricularly administered urocortin inhibits gastric emptying in mice. Int J Mol Med 15: 1041-1043, 2005
APA
Nagata, T., Uemoto, M., Yuzuriha, H., Asakawa, A., Inui, A., Fujimiya, M. ... Shinfuku, N. (2005). Intracerebroventricularly administered urocortin inhibits gastric emptying in mice. International Journal of Molecular Medicine, 15, 1041-1043. https://doi.org/10.3892/ijmm.15.6.1041
MLA
Nagata, T., Uemoto, M., Yuzuriha, H., Asakawa, A., Inui, A., Fujimiya, M., Sakamaki, R., Kasuga, M., Shinfuku, N."Intracerebroventricularly administered urocortin inhibits gastric emptying in mice". International Journal of Molecular Medicine 15.6 (2005): 1041-1043.
Chicago
Nagata, T., Uemoto, M., Yuzuriha, H., Asakawa, A., Inui, A., Fujimiya, M., Sakamaki, R., Kasuga, M., Shinfuku, N."Intracerebroventricularly administered urocortin inhibits gastric emptying in mice". International Journal of Molecular Medicine 15, no. 6 (2005): 1041-1043. https://doi.org/10.3892/ijmm.15.6.1041