C-514T polymorphism in hepatic lipase gene promoter is associated with elevated triglyceride levels and decreasing insulin sensitivity in nondiabetic Japanese subjects

  • Authors:
    • Yasuyoshi Yabu
    • Katsura Noma
    • Kaname Nakatani
    • Junji Nishioka
    • Mina Suematsu
    • Akira Katsuki
    • Yasuko Hori
    • Yutaka Yano
    • Yasuhiro Sumida
    • Hideo Wada
    • Tsutomu Nobori
  • View Affiliations

  • Published online on: September 1, 2005     https://doi.org/10.3892/ijmm.16.3.421
  • Pages: 421-425
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Abstract

Hepatic lipase (HL) is synthesized in the liver and hydrolyses triglyceride and phospholipids. C-514T polymorphism in HL gene promoter was reported to associate with hepatic lipase activity and plasma lipid levels. We examined whether C-514T polymorphism affects glucose metabolism beyond its effect on plasma lipid levels in nondiabetic Japanese subjects. Gene frequencies of C/C homozygote, C/T heterozygote and T/T homozygote were 18, 51 and 31%, respectively. The allelic frequencies of C and T were 44 and 56%, respectively. T allele frequency was much higher than in Caucasian subjects. Moreover, -514T allele carriers had higher levels of triglyceride (P=0.027), fasting insulin (P=0.016) and HOMA-IR (P=0.033) than non-carriers. In contrast to some former studies, -514T allele affected triglyceride levels and insulin sensitivity. Taken together, HL gene might be one of the important susceptibility genes of type 2 diabetes and the high incidence of type 2 diabetes could be explained by high frequency of -514T allele in the Japanese population. Moreover, since HL and adiponectin showed an additive effect on insulin sensitivity, these genetic variations can be independently associated with insulin sensitivity.

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September 2005
Volume 16 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Yabu Y, Noma K, Nakatani K, Nishioka J, Suematsu M, Katsuki A, Hori Y, Yano Y, Sumida Y, Wada H, Wada H, et al: C-514T polymorphism in hepatic lipase gene promoter is associated with elevated triglyceride levels and decreasing insulin sensitivity in nondiabetic Japanese subjects. Int J Mol Med 16: 421-425, 2005
APA
Yabu, Y., Noma, K., Nakatani, K., Nishioka, J., Suematsu, M., Katsuki, A. ... Nobori, T. (2005). C-514T polymorphism in hepatic lipase gene promoter is associated with elevated triglyceride levels and decreasing insulin sensitivity in nondiabetic Japanese subjects. International Journal of Molecular Medicine, 16, 421-425. https://doi.org/10.3892/ijmm.16.3.421
MLA
Yabu, Y., Noma, K., Nakatani, K., Nishioka, J., Suematsu, M., Katsuki, A., Hori, Y., Yano, Y., Sumida, Y., Wada, H., Nobori, T."C-514T polymorphism in hepatic lipase gene promoter is associated with elevated triglyceride levels and decreasing insulin sensitivity in nondiabetic Japanese subjects". International Journal of Molecular Medicine 16.3 (2005): 421-425.
Chicago
Yabu, Y., Noma, K., Nakatani, K., Nishioka, J., Suematsu, M., Katsuki, A., Hori, Y., Yano, Y., Sumida, Y., Wada, H., Nobori, T."C-514T polymorphism in hepatic lipase gene promoter is associated with elevated triglyceride levels and decreasing insulin sensitivity in nondiabetic Japanese subjects". International Journal of Molecular Medicine 16, no. 3 (2005): 421-425. https://doi.org/10.3892/ijmm.16.3.421