Laughter therapy modulates the parameters of renin-angiotensin system in patients with type 2 diabetes

  • Authors:
    • Uddin Mohammad Nasir
    • Shizuko Iwanaga
    • A. H.M. Nurun Nabi
    • Osamu Urayama
    • Keiko Hayashi
    • Takashi Hayashi
    • Koichi Kawai
    • Afroza Sultana
    • Kazuo Murakami
    • Fumiaki Suzuki
  • View Affiliations

  • Published online on: December 1, 2005     https://doi.org/10.3892/ijmm.16.6.1077
  • Pages: 1077-1081
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Abstract

The effect of laughter therapy on the plasma levels of renin, angiotensinogen, and prorenin was investigated in patients with type 2 diabetes. In the diabetic patients, the mean plasma renin concentrations were 24.6±12.1 ng/ml/h in the first observation (at the beginning of laughter therapy), 8.2±3.4 ng/ml/h in the second observation (three months after the beginning of laughter therapy) and 7.7±1.7 ng/ml/h in the third observation (six months after the beginning of laughter therapy). The mean plasma angiotensinogen concentrations in the 1st, 2nd and 3rd observations were 0.19±0.08, 0.47±0.12, 0.42±0.14 µg/ml, respectively. The mean plasma prorenin concentrations in the 1st, 2nd and 3rd observations during the laughter therapy were 195.1±66.2, 193.4±88.2 and 170.7±52.5 pg/ml, respectively. Plasma renin concentrations were significantly decreased (p<0.05) by the therapy. Subnormal concentrations of plasma angiotensinogen were found in the 1st observation and increased significantly (p<0.05) to the normal range after the therapy. Plasma prorenin concentration only slightly changed during the laughter therapy. Other biochemical parameters remained unchanged during the laughter therapy. These results indicated that a long-term laughter therapy changed the plasma components of renin-angiotensin system in patients with diabetes. Thus, laughter therapy can be used as non-pharmacological treatment for the prevention of diabetic microvascular complications.

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December 2005
Volume 16 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Nasir UM, Iwanaga S, Nabi AH, Urayama O, Hayashi K, Hayashi T, Kawai K, Sultana A, Murakami K, Suzuki F, Suzuki F, et al: Laughter therapy modulates the parameters of renin-angiotensin system in patients with type 2 diabetes. Int J Mol Med 16: 1077-1081, 2005
APA
Nasir, U.M., Iwanaga, S., Nabi, A.H., Urayama, O., Hayashi, K., Hayashi, T. ... Suzuki, F. (2005). Laughter therapy modulates the parameters of renin-angiotensin system in patients with type 2 diabetes. International Journal of Molecular Medicine, 16, 1077-1081. https://doi.org/10.3892/ijmm.16.6.1077
MLA
Nasir, U. M., Iwanaga, S., Nabi, A. H., Urayama, O., Hayashi, K., Hayashi, T., Kawai, K., Sultana, A., Murakami, K., Suzuki, F."Laughter therapy modulates the parameters of renin-angiotensin system in patients with type 2 diabetes". International Journal of Molecular Medicine 16.6 (2005): 1077-1081.
Chicago
Nasir, U. M., Iwanaga, S., Nabi, A. H., Urayama, O., Hayashi, K., Hayashi, T., Kawai, K., Sultana, A., Murakami, K., Suzuki, F."Laughter therapy modulates the parameters of renin-angiotensin system in patients with type 2 diabetes". International Journal of Molecular Medicine 16, no. 6 (2005): 1077-1081. https://doi.org/10.3892/ijmm.16.6.1077