STI571 (Glivec) induces cell death in the gastrointestinal stromal tumor cell line, GIST-T1, via endoplasmic reticulum stress response

  • Authors:
    • Hajime Nakatani
    • Keijiro Araki
    • Toufeng Jin
    • Michiya Kobayashi
    • Takeki Sugimoto
    • Toyokazu Akimori
    • Tsutomu Namikawa
    • Ken Okamoto
    • Takumi Nakano
    • Takehiro Okabayashi
    • Norihiro Hokimoto
    • Hiroyuki Kitagawa
    • Takahiro Taguchi
  • View Affiliations

  • Published online on: May 1, 2006     https://doi.org/10.3892/ijmm.17.5.893
  • Pages: 893-897
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Abstract

STI571 is a specific inhibitor of tyrosine kinases, such as BCR-ABL, platelet-derived growth factor receptor, and c-KIT, and has recently been approved for the treatment of chronic myeloid leukemia and gastrointestinal stromal tumors (GISTs). This study demonstrated that STI571 induces cell death in the gastrointestinal stromal tumor cell line, GIST-T1. In these cells, STI571 induced pro-caspase-12 or pro-caspase-7 cleavage and it affected caspase-3 activity and induced the endoplasmic reticulum (ER)-resident chaperone, glucose-regulated protein 78. The STI571-induced cell death was blocked by the protein synthesis inhibitor, cycloheximide. Together, these results suggest that STI571 induces cell death in GIST-T1 cells, at least in part, via the ER stress response.

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May 2006
Volume 17 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Nakatani H, Araki K, Jin T, Kobayashi M, Sugimoto T, Akimori T, Namikawa T, Okamoto K, Nakano T, Okabayashi T, Okabayashi T, et al: STI571 (Glivec) induces cell death in the gastrointestinal stromal tumor cell line, GIST-T1, via endoplasmic reticulum stress response. Int J Mol Med 17: 893-897, 2006
APA
Nakatani, H., Araki, K., Jin, T., Kobayashi, M., Sugimoto, T., Akimori, T. ... Taguchi, T. (2006). STI571 (Glivec) induces cell death in the gastrointestinal stromal tumor cell line, GIST-T1, via endoplasmic reticulum stress response. International Journal of Molecular Medicine, 17, 893-897. https://doi.org/10.3892/ijmm.17.5.893
MLA
Nakatani, H., Araki, K., Jin, T., Kobayashi, M., Sugimoto, T., Akimori, T., Namikawa, T., Okamoto, K., Nakano, T., Okabayashi, T., Hokimoto, N., Kitagawa, H., Taguchi, T."STI571 (Glivec) induces cell death in the gastrointestinal stromal tumor cell line, GIST-T1, via endoplasmic reticulum stress response". International Journal of Molecular Medicine 17.5 (2006): 893-897.
Chicago
Nakatani, H., Araki, K., Jin, T., Kobayashi, M., Sugimoto, T., Akimori, T., Namikawa, T., Okamoto, K., Nakano, T., Okabayashi, T., Hokimoto, N., Kitagawa, H., Taguchi, T."STI571 (Glivec) induces cell death in the gastrointestinal stromal tumor cell line, GIST-T1, via endoplasmic reticulum stress response". International Journal of Molecular Medicine 17, no. 5 (2006): 893-897. https://doi.org/10.3892/ijmm.17.5.893