Reduced metastatic potential and c-myc overexpression of colon adenocarcinoma cells (Colon 26 line) transfected with nm23-R2/rat nucleoside diphosphate kinase alpha isoform.

  • Authors:
    • H Tagashira
    • K Hamazaki
    • N Tanaka
    • C Gao
    • M Namba
  • View Affiliations

  • Published online on: July 1, 1998     https://doi.org/10.3892/ijmm.2.1.65
  • Pages: 65-73
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Abstract

Increased expression of nm23/nucleoside diphosphate kinase (NDP kinase) has been reported to be associated with both reduced metastatic potential in breast carcinoma and tumor progression in colon adenocarcinoma and lung adenocarcinoma. We examined effects of expression of nm23-R2 rat NDP kinase alpha isoform on mouse adenocarcinoma cells (Colon 26 line) and found a significant reduction of metastatic potential along with overexpression of c-myc. We also found that the proliferation rate of the transformed cells was the same as that of the control cells in culture. These results indicate that the cell growth potential in vitro is irrelevant to metastatic potential of the cells in vivo.

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Jul 1998
Volume 2 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Tagashira H, Hamazaki K, Tanaka N, Gao C and Namba M: Reduced metastatic potential and c-myc overexpression of colon adenocarcinoma cells (Colon 26 line) transfected with nm23-R2/rat nucleoside diphosphate kinase alpha isoform.. Int J Mol Med 2: 65-73, 1998
APA
Tagashira, H., Hamazaki, K., Tanaka, N., Gao, C., & Namba, M. (1998). Reduced metastatic potential and c-myc overexpression of colon adenocarcinoma cells (Colon 26 line) transfected with nm23-R2/rat nucleoside diphosphate kinase alpha isoform.. International Journal of Molecular Medicine, 2, 65-73. https://doi.org/10.3892/ijmm.2.1.65
MLA
Tagashira, H., Hamazaki, K., Tanaka, N., Gao, C., Namba, M."Reduced metastatic potential and c-myc overexpression of colon adenocarcinoma cells (Colon 26 line) transfected with nm23-R2/rat nucleoside diphosphate kinase alpha isoform.". International Journal of Molecular Medicine 2.1 (1998): 65-73.
Chicago
Tagashira, H., Hamazaki, K., Tanaka, N., Gao, C., Namba, M."Reduced metastatic potential and c-myc overexpression of colon adenocarcinoma cells (Colon 26 line) transfected with nm23-R2/rat nucleoside diphosphate kinase alpha isoform.". International Journal of Molecular Medicine 2, no. 1 (1998): 65-73. https://doi.org/10.3892/ijmm.2.1.65