Cementum attachment protein/protein-tyrosine phosphotase-like member A is not expressed in teeth

  • Authors:
    • Christof Schild
    • Michael Beyeler
    • Niklaus P. Lang
    • Beat Trueb
  • View Affiliations

  • Published online on: February 1, 2009     https://doi.org/10.3892/ijmm_00000130
  • Pages: 293-296
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Abstract

SCementum is a highly specialized connective tissue that covers tooth roots. The only cementum-specific protein described to date is the cementum attachment protein (CAP). A putative sequence for CAP was established from a cDNA clone isolated from a human cementifying fibroma cDNA library. This sequence overlaps with a phosphatase-like protein in muscle termed the protein-tyrosine phosphatase-like member A (PTPLA). To clarify the nature of CAP/PTPLA, we cloned the homologous rat protein and determined its sequence. The rat protein shared 94% sequence identity with the human protein. On Northern blots containing RNA from various rat tissues of different developmental stages, the cDNA hybridized to an mRNA expressed in heart and skeletal muscle but not in teeth. These results were confirmed by real-time PCR. Thus, the sequence deposited in public databanks under the name ‘cementum attachment protein’ does not represent genuine CAP.

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February 2009
Volume 23 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Schild C, Beyeler M, Lang NP and Trueb B: Cementum attachment protein/protein-tyrosine phosphotase-like member A is not expressed in teeth. Int J Mol Med 23: 293-296, 2009
APA
Schild, C., Beyeler, M., Lang, N.P., & Trueb, B. (2009). Cementum attachment protein/protein-tyrosine phosphotase-like member A is not expressed in teeth. International Journal of Molecular Medicine, 23, 293-296. https://doi.org/10.3892/ijmm_00000130
MLA
Schild, C., Beyeler, M., Lang, N. P., Trueb, B."Cementum attachment protein/protein-tyrosine phosphotase-like member A is not expressed in teeth". International Journal of Molecular Medicine 23.2 (2009): 293-296.
Chicago
Schild, C., Beyeler, M., Lang, N. P., Trueb, B."Cementum attachment protein/protein-tyrosine phosphotase-like member A is not expressed in teeth". International Journal of Molecular Medicine 23, no. 2 (2009): 293-296. https://doi.org/10.3892/ijmm_00000130