Association of gene polymorphisms with chronic kidney disease in high- or low-risk subjects defined by conventional risk factors

  • Authors:
    • Tetsuro Yoshida
    • Kimihiko Kato
    • Kiyoshi Yokoi
    • Mitsutoshi Oguri
    • Sachiro Watanabe
    • Norifumi Metoki
    • Hidemi Yoshida
    • Kei Satoh
    • Yukitoshi Aoyagi
    • Yutaka Nishigaki
    • Yoshinori Nozawa
    • Yoshiji Yamada
  • View Affiliations

  • Published online on: June 1, 2009     https://doi.org/10.3892/ijmm_00000193
  • Pages: 785-792
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Abstract

The purpose of the present study was to identify genetic variants which confer susceptibility to chronic kidney disease (CKD) in high- or low-risk subjects defined by conventional risk factors separately. The study population comprised 2828 Japanese individuals, including 434 subjects with CKD [estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2] and 2394 controls (eGFR ≥60 ml/min/ 1.73 m2). The 1012 high-risk subjects had both hypertension and diabetes mellitus, and the 1816 low-risk subjects had none of these conditions. The genotypes for 296 polymorphisms of 202 candidate genes were determined. The Chi-square test, multivariable logistic regression analysis with adjustment for covariates, as well as a stepwise forward selection procedure revealed that ten different polymorphisms were associated (P<0.05) with the prevalence of CKD in high- or low-risk subjects: the -519A↷G polymorphism of MMP1, the 1061A↷G (Ile405Val) polymorphism of CETP, the A↷G (Lys45Glu) polymorphism of MMP3, the -219G↷T polymorphism of APOE, the A↷G (Ile1205Val) polymorphism of COL3A1, the -863C↷A polymorphism of TNF, and the 1454C↷G (Leu125Val) polymorphism of PECAM1 in high-risk subjects; and the 1167C↷T (Asn389Asn) polymorphism of TGFBR2, the 2386A↷G (Ile796Val) polymorphism of SCAP, and the TAAA↷del polymorphism of PDE4D in low-risk subjects. Among these polymorphisms, the -519A↷G polymorphism of MMP1 and the 1167C↷T (Asn389Asn) polymorphism of TGFBR2 were most significantly associated with CKD in high- or low-risk individuals, respectively. These results suggest that polymorphisms associated with CKD may differ among high- or low-risk subjects. Stratification of subjects according to conventional risk factors may thus be important for personalized prevention of CKD based on genetic information.

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June 2009
Volume 23 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Nishigaki Y, et al: Association of gene polymorphisms with chronic kidney disease in high- or low-risk subjects defined by conventional risk factors. Int J Mol Med 23: 785-792, 2009
APA
Yoshida, T., Kato, K., Yokoi, K., Oguri, M., Watanabe, S., Metoki, N. ... Yamada, Y. (2009). Association of gene polymorphisms with chronic kidney disease in high- or low-risk subjects defined by conventional risk factors. International Journal of Molecular Medicine, 23, 785-792. https://doi.org/10.3892/ijmm_00000193
MLA
Yoshida, T., Kato, K., Yokoi, K., Oguri, M., Watanabe, S., Metoki, N., Yoshida, H., Satoh, K., Aoyagi, Y., Nishigaki, Y., Nozawa, Y., Yamada, Y."Association of gene polymorphisms with chronic kidney disease in high- or low-risk subjects defined by conventional risk factors". International Journal of Molecular Medicine 23.6 (2009): 785-792.
Chicago
Yoshida, T., Kato, K., Yokoi, K., Oguri, M., Watanabe, S., Metoki, N., Yoshida, H., Satoh, K., Aoyagi, Y., Nishigaki, Y., Nozawa, Y., Yamada, Y."Association of gene polymorphisms with chronic kidney disease in high- or low-risk subjects defined by conventional risk factors". International Journal of Molecular Medicine 23, no. 6 (2009): 785-792. https://doi.org/10.3892/ijmm_00000193