Gossypol inhibits the growth of MAT-LyLu prostate cancer cells by modulation of TGFβ/Akt signaling

  • Authors:
    • Jiahua Jiang
    • Weiping Ye
    • Young c. Lin
  • View Affiliations

  • Published online on: July 1, 2009     https://doi.org/10.3892/ijmm_00000208
  • Pages: 69-75
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Abstract

Gossypol (GP), a male contraceptive compound naturally present in cottonseed products, possesses anti-proliferative and anti-metastatic effects in vitro and in vivo. However, the detailed mechanisms responsible for the effects of GP on the cell cycle of prostate cancer cells remain to be elucidated. In the present study, we investigated the effects of GP on the regulation of the cell cycle of rodent prostate cancer MAT-LyLu cells and the mechanisms of GP-induced growth inhibition. Our results showed that GP inhibited the cell proliferation and colony formation in a dose-dependent manner by the up-regulation of expression and secretion of transforming growth factor β1 (TGFβ1) and down-regulation of expression of Akt and phospho-Akt protein. The inhibition of cell growth was also demonstrated by cell cycle arrest at G0/G1 phase. Furthermore, GP decreased the expression of cyclin D1, Cdk4 and phospho-Rb in MAT-LyLu cells. Thus, the inhibitory effects of GP on the proliferation of MAT-LyLu prostate cancer cells are associated with modulation of TGFβ1 and Akt signaling, which influence the expression of regulatory proteins such as cyclin D1, Cdk4 and phospho-Rb which regulate cell cycle progression of prostate cancer cells.

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July 2009
Volume 24 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Jiang J, Ye W and Lin Yc: Gossypol inhibits the growth of MAT-LyLu prostate cancer cells by modulation of TGFβ/Akt signaling. Int J Mol Med 24: 69-75, 2009
APA
Jiang, J., Ye, W., & Lin, Y.c. (2009). Gossypol inhibits the growth of MAT-LyLu prostate cancer cells by modulation of TGFβ/Akt signaling. International Journal of Molecular Medicine, 24, 69-75. https://doi.org/10.3892/ijmm_00000208
MLA
Jiang, J., Ye, W., Lin, Y. c."Gossypol inhibits the growth of MAT-LyLu prostate cancer cells by modulation of TGFβ/Akt signaling". International Journal of Molecular Medicine 24.1 (2009): 69-75.
Chicago
Jiang, J., Ye, W., Lin, Y. c."Gossypol inhibits the growth of MAT-LyLu prostate cancer cells by modulation of TGFβ/Akt signaling". International Journal of Molecular Medicine 24, no. 1 (2009): 69-75. https://doi.org/10.3892/ijmm_00000208