Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-κB activation

  • Authors:
    • Masayuki Nishida
    • Shin Nishiumi
    • Yoshiyuki Mizushina
    • Yoshimi Fujishima
    • Koji Yamamoto
    • Atsuhiro Masuda
    • Shigeto Mizuno
    • Tsuyoshi Fujita
    • Yoshinori Morita
    • Hiromu Kutsumi
    • Hiromi Yoshida
    • Takeshi Azuma
    • Masaru Yoshida
  • View Affiliations

  • Published online on: May 1, 2010     https://doi.org/10.3892/ijmm_00000402
  • Pages: 761-767
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Curcumin, a component of turmeric (Curcuma longa), is known to exert a variety of biological functions including anti-inflammatory activity. We examined the inhibitory effects of chemically synthesized derivatives of curcumin against inflammatory responses and compared them with those of curcumin, in order to find derivatives with stronger effects than curcumin. In a cell culture system using the mouse macrophage cell line RAW264.7, monoacetylcurcumin strongly inhibited IκB phosphorylation, nuclear factor (NF)-κB activation and tumor necrosis factor (TNF)-α production induced by lipopolysaccharide (LPS). In addition, oral administration of monoacetylcurcumin to mice led to greater suppression of TNF-α production after LPS stimulation than the administration of curcumin or tetrahydrocurcumin in vivo. Monoacetylcurcumin also inhibited the LPS-induced NF-κB activation in the liver. Collectively, monoacetylcurcumin is a potential chemopreventive agent for treating inflammatory responses more effectively than curcumin.

Related Articles

Journal Cover

May 2010
Volume 25 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Nishida M, Nishiumi S, Mizushina Y, Fujishima Y, Yamamoto K, Masuda A, Mizuno S, Fujita T, Morita Y, Kutsumi H, Kutsumi H, et al: Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-κB activation. Int J Mol Med 25: 761-767, 2010
APA
Nishida, M., Nishiumi, S., Mizushina, Y., Fujishima, Y., Yamamoto, K., Masuda, A. ... Yoshida, M. (2010). Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-κB activation. International Journal of Molecular Medicine, 25, 761-767. https://doi.org/10.3892/ijmm_00000402
MLA
Nishida, M., Nishiumi, S., Mizushina, Y., Fujishima, Y., Yamamoto, K., Masuda, A., Mizuno, S., Fujita, T., Morita, Y., Kutsumi, H., Yoshida, H., Azuma, T., Yoshida, M."Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-κB activation". International Journal of Molecular Medicine 25.5 (2010): 761-767.
Chicago
Nishida, M., Nishiumi, S., Mizushina, Y., Fujishima, Y., Yamamoto, K., Masuda, A., Mizuno, S., Fujita, T., Morita, Y., Kutsumi, H., Yoshida, H., Azuma, T., Yoshida, M."Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-κB activation". International Journal of Molecular Medicine 25, no. 5 (2010): 761-767. https://doi.org/10.3892/ijmm_00000402