Inability of NCoR/SMRT to repress androgen receptor transcriptional activity in prostate cancer cell lines

  • Authors:
    • Martin Laschak
    • Marina Bechtel
    • Klaus-Dieter Spindler
    • Andrea Hessenauer
  • View Affiliations

  • Published online on: June 27, 2011     https://doi.org/10.3892/ijmm.2011.735
  • Pages: 645-651
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Abstract

The molecular mechanisms leading to castration-resistant prostate cancer (CRPC) are poorly understood. Among several mechanisms leading to CRPC growth a dysregulation of androgen receptor (AR) co-regulators (i.e. up-regulation of co-activators or down-regulation of co-repressors) is discussed. There are numerous reports demonstrating an increased expression of co-activators during prostate cancer progression. On the contrary, the impact of co-repressors on tumor growth and development is less clear. In this study we compared the effects of two known co-repressors, NCoR and SMRT, on AR transcriptional activity in prostate cancer (PCa) cell lines and compared them to that in COS-1 cells. Interestingly, we found that NCoR/SMRT overexpression did not repress AR-dependent gene expression in the PCa cell lines, but rather activated it. This finding is probably due to an impaired AR-co-repressor interaction in the prostate cancer cell lines. In conclusion, we provide evidence that up-regulation of NCoR or SMRT may increase transcriptional activity of the AR in a cell type-specific context.

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October 2011
Volume 28 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Laschak M, Bechtel M, Spindler K and Hessenauer A: Inability of NCoR/SMRT to repress androgen receptor transcriptional activity in prostate cancer cell lines. Int J Mol Med 28: 645-651, 2011
APA
Laschak, M., Bechtel, M., Spindler, K., & Hessenauer, A. (2011). Inability of NCoR/SMRT to repress androgen receptor transcriptional activity in prostate cancer cell lines. International Journal of Molecular Medicine, 28, 645-651. https://doi.org/10.3892/ijmm.2011.735
MLA
Laschak, M., Bechtel, M., Spindler, K., Hessenauer, A."Inability of NCoR/SMRT to repress androgen receptor transcriptional activity in prostate cancer cell lines". International Journal of Molecular Medicine 28.4 (2011): 645-651.
Chicago
Laschak, M., Bechtel, M., Spindler, K., Hessenauer, A."Inability of NCoR/SMRT to repress androgen receptor transcriptional activity in prostate cancer cell lines". International Journal of Molecular Medicine 28, no. 4 (2011): 645-651. https://doi.org/10.3892/ijmm.2011.735