Overexpression of the small GTPase Arl4D suppresses adipogenesis

  • Authors:
    • Jiahua Yu
    • Sun-O Ka
    • Kang-Beom Kwon
    • Sang-Myeong Lee
    • Jin-Woo Park
    • Byung-Hyun Park
  • View Affiliations

  • Published online on: July 15, 2011     https://doi.org/10.3892/ijmm.2011.751
  • Pages: 793-798
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Abstract

Arl4D is a developmentally-regulated member of the ADP-ribosylation factor/ARF-like protein (ARF/Arl) family of Ras-related GTPases. Although Arl4 protein is reported to be expressed in adipose tissue, the function of Arl4D is unknown. To investigate the potential role of Arl4D in adipogenesis, we examined Arl4D expression during adipocyte differentiation and the effects of Arl4D overexpression on adipogenesis. Arl4D protein increased early in adipogenesis, with the highest expression at 4 h after adipogenesis initiation, followed by a decrease thereafter. Overexpression of Arl4D in 3T3-L1 cells potently inhibited their ability to differentiate and accumulate lipid, and reduced the expression of adipogenic genes. Furthermore, treatment with valproic acid, an Arl4D inducer, suppressed adipogenesis. These results suggest that rapid reduction of Arl4D is required for adipogenesis to proceed.

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November 2011
Volume 28 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Yu J, Ka S, Kwon K, Lee S, Park J and Park B: Overexpression of the small GTPase Arl4D suppresses adipogenesis. Int J Mol Med 28: 793-798, 2011
APA
Yu, J., Ka, S., Kwon, K., Lee, S., Park, J., & Park, B. (2011). Overexpression of the small GTPase Arl4D suppresses adipogenesis. International Journal of Molecular Medicine, 28, 793-798. https://doi.org/10.3892/ijmm.2011.751
MLA
Yu, J., Ka, S., Kwon, K., Lee, S., Park, J., Park, B."Overexpression of the small GTPase Arl4D suppresses adipogenesis". International Journal of Molecular Medicine 28.5 (2011): 793-798.
Chicago
Yu, J., Ka, S., Kwon, K., Lee, S., Park, J., Park, B."Overexpression of the small GTPase Arl4D suppresses adipogenesis". International Journal of Molecular Medicine 28, no. 5 (2011): 793-798. https://doi.org/10.3892/ijmm.2011.751