Mitigation of 2,4-dinitrofluorobenzene-induced atopic dermatitis-related symptoms by Terminalia chebula Retzius

  • Authors:
    • Dong-Yoon Nam
    • Jin-Man Lee
    • Jin-Chul Heo
    • Sang-Han Lee
  • View Affiliations

  • Published online on: September 7, 2011     https://doi.org/10.3892/ijmm.2011.792
  • Pages: 1013-1018
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Abstract

To evaluate whether an aqueous seed extract of Terminalia chebula Retzius inhibited development of atopy in vivo, we used a 2,4-dinitrofluorobenzene (DNFB)-induced animal model of atopic symptoms to investigate the effects of the extract. We measured CD4+ cell numbers by hematoxylin and eosin (H&E) staining, and determined the expression levels of matrix metalloproteinase (MMP)-9, interleukin (IL)-31, and T-bet genes, in this animal model. The data showed that a Terminalia chebula extract (100 µg/ml) exhibited strong anti-atopic activity, mediating a 52% reduction in the immune response, as measured by thickness of ear swelling, and resulting in decreased eosinophil levels in adjacent skin tissue. Collectively, the results indicate that a Terminalia chebula seed extract has potential for alleviation of atopy-like symptoms induced by DNFB in the mouse.

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December 2011
Volume 28 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Nam D, Lee J, Heo J and Lee S: Mitigation of 2,4-dinitrofluorobenzene-induced atopic dermatitis-related symptoms by Terminalia chebula Retzius. Int J Mol Med 28: 1013-1018, 2011
APA
Nam, D., Lee, J., Heo, J., & Lee, S. (2011). Mitigation of 2,4-dinitrofluorobenzene-induced atopic dermatitis-related symptoms by Terminalia chebula Retzius. International Journal of Molecular Medicine, 28, 1013-1018. https://doi.org/10.3892/ijmm.2011.792
MLA
Nam, D., Lee, J., Heo, J., Lee, S."Mitigation of 2,4-dinitrofluorobenzene-induced atopic dermatitis-related symptoms by Terminalia chebula Retzius". International Journal of Molecular Medicine 28.6 (2011): 1013-1018.
Chicago
Nam, D., Lee, J., Heo, J., Lee, S."Mitigation of 2,4-dinitrofluorobenzene-induced atopic dermatitis-related symptoms by Terminalia chebula Retzius". International Journal of Molecular Medicine 28, no. 6 (2011): 1013-1018. https://doi.org/10.3892/ijmm.2011.792