Delayed healing and induction of secretory leukocyte protease inhibitor in polycystic ovary syndrome rat skin wounds

  • Authors:
    • Soon-Jeong Jeong
    • Sung-Shin Kim
    • Chun-Sik Bae
    • Jin-Ju Park
    • Baik-Dong Choi
    • Guanlin Wang
    • Myung-Ju Jung
    • Hyun-Sun Jang
    • Byung-Ock Kim
    • Do-Seon Lim
    • Young-Sik Cho
    • Moon-Jin Jeong
  • View Affiliations

  • Published online on: October 20, 2011     https://doi.org/10.3892/ijmm.2011.816
  • Pages: 185-194
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Abstract

Secretory leukocyte protease inhibitor (SLPI) and estrogen promote wound healing through a decrease in the excessive inflammatory response, accelerating re-epithelialization and increasing the amount of collagen deposition. The excessive administration of estradiol valerate (EV) using hormonal therapy decreases the concentration of estrogen abruptly and induces the polycystic ovary syndrome (PCOS). In this study, the PCOS rat skin wound area was wider than that of the normal groups and the rate of keratinocyte migration in PCOS was lower than the normal group. The numbers of inflammatory cells and macrophages recruited in the PCOS group were larger than that of the normal group. More collagen was deposited in the healing area of the normal group than in the PCOS group. The level of SLPI expression was higher in the PCOS group than the normal group after wounding, with the exception of the epithelium. On the other hand, mRNA and protein expression levels of transforming growth factor-β1 (TGF-β1) were lower in the PCOS group than in the normal group. Matrix metalloproteinase-2 (MMP-2) and MMP-9 levels in the PCOS group were significantly lower than that of the normal group. Therefore, increased SLPI in PCOS skin wounds may help prevent an excessive inflammatory response and aberrant collagen deposition but not are sufficient to accelerate PCOS skin wound healing, suggesting that SLPI may act as a local rather than a systemic modulating molecule in PCOS rat skin wounds.

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February 2012
Volume 29 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Jeong S, Kim S, Bae C, Park J, Choi B, Wang G, Jung M, Jang H, Kim B, Lim D, Lim D, et al: Delayed healing and induction of secretory leukocyte protease inhibitor in polycystic ovary syndrome rat skin wounds. Int J Mol Med 29: 185-194, 2012
APA
Jeong, S., Kim, S., Bae, C., Park, J., Choi, B., Wang, G. ... Jeong, M. (2012). Delayed healing and induction of secretory leukocyte protease inhibitor in polycystic ovary syndrome rat skin wounds. International Journal of Molecular Medicine, 29, 185-194. https://doi.org/10.3892/ijmm.2011.816
MLA
Jeong, S., Kim, S., Bae, C., Park, J., Choi, B., Wang, G., Jung, M., Jang, H., Kim, B., Lim, D., Cho, Y., Jeong, M."Delayed healing and induction of secretory leukocyte protease inhibitor in polycystic ovary syndrome rat skin wounds". International Journal of Molecular Medicine 29.2 (2012): 185-194.
Chicago
Jeong, S., Kim, S., Bae, C., Park, J., Choi, B., Wang, G., Jung, M., Jang, H., Kim, B., Lim, D., Cho, Y., Jeong, M."Delayed healing and induction of secretory leukocyte protease inhibitor in polycystic ovary syndrome rat skin wounds". International Journal of Molecular Medicine 29, no. 2 (2012): 185-194. https://doi.org/10.3892/ijmm.2011.816