Protocadherin-10 is involved in angiogenesis and methylation correlated with multiple myeloma

  • Authors:
    • Ying Li
    • Ze-song Yang
    • Jun-jun Song
    • Qiong Liu
    • Jian-bin Chen
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  • Published online on: January 9, 2012     https://doi.org/10.3892/ijmm.2012.880
  • Pages: 704-710
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Abstract

Protocadherin-10 (PCDH10) which is located at 4q28.3, is a member of the cadherin superfamily of cell adhesion molecules. PCDH10 is broadly expressed in normal adult, but nearly undetectable in multiple myeloma (ΜΜ) tissues and cell lines. Its promoter methylation was detected in virtually all the silenced or downregulated cell lines. The silencing of PCDH10 could be reversed by pharmacological demethylation, indicating a methylation-mediated mechanism. In the current study, we investigated 44 patients (23 females, 21 males), 77.27% (34/44) of whom presented high methylation of PCDH10. We found no associations between promoter hypermethylation and gender or age at the time of initial diagnosis. We also examined the role of PCDH10 as a mediator of MM cell proliferation, cell cycle progression, and its involvement in angiogenesis. Our results demonstrate that the PCDH10 gene is a target for epigenetic silencing in MM and provide a link between the dysregulation of angiogenesis and DNA methylation.
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April 2012
Volume 29 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Li Y, Yang Z, Song J, Liu Q and Chen J: Protocadherin-10 is involved in angiogenesis and methylation correlated with multiple myeloma. Int J Mol Med 29: 704-710, 2012
APA
Li, Y., Yang, Z., Song, J., Liu, Q., & Chen, J. (2012). Protocadherin-10 is involved in angiogenesis and methylation correlated with multiple myeloma. International Journal of Molecular Medicine, 29, 704-710. https://doi.org/10.3892/ijmm.2012.880
MLA
Li, Y., Yang, Z., Song, J., Liu, Q., Chen, J."Protocadherin-10 is involved in angiogenesis and methylation correlated with multiple myeloma". International Journal of Molecular Medicine 29.4 (2012): 704-710.
Chicago
Li, Y., Yang, Z., Song, J., Liu, Q., Chen, J."Protocadherin-10 is involved in angiogenesis and methylation correlated with multiple myeloma". International Journal of Molecular Medicine 29, no. 4 (2012): 704-710. https://doi.org/10.3892/ijmm.2012.880