Heterogeneous expression of P450 2C12 mRNA in female rat liver.

  • Authors:
    • T Okamoto
    • R Yamamoto
  • View Affiliations

  • Published online on: February 1, 1999     https://doi.org/10.3892/ijmm.3.2.215
  • Pages: 215-221
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Abstract

The heterogeneous expression of P450 2C12 mRNA was studied in the rat liver. Liver was sampled from female rat, approximately 40 mg portions being removed from 18 different locations. Total RNA was isolated and subjected to northern blot analysis. The membrane was hybridized with a (32)P-labeled rat P450 2C12 gene-specific oligonucleotide probe. After the hybridized P450 2C12 gene-specific probe had been washed out, the membrane was hybridized again with a rat oligonucleotide probe for the detection of actin mRNA expression. In comparison with actin mRNA expression, P450 2C12 mRNA was not evenly expressed throughout the 18 different locations in the liver. The present results show the heterogeneous expression of P450 2C12 mRNA in the rat liver.

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Feb 1999
Volume 3 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Okamoto T and Okamoto T: Heterogeneous expression of P450 2C12 mRNA in female rat liver.. Int J Mol Med 3: 215-221, 1999
APA
Okamoto, T., & Okamoto, T. (1999). Heterogeneous expression of P450 2C12 mRNA in female rat liver.. International Journal of Molecular Medicine, 3, 215-221. https://doi.org/10.3892/ijmm.3.2.215
MLA
Okamoto, T., Yamamoto, R."Heterogeneous expression of P450 2C12 mRNA in female rat liver.". International Journal of Molecular Medicine 3.2 (1999): 215-221.
Chicago
Okamoto, T., Yamamoto, R."Heterogeneous expression of P450 2C12 mRNA in female rat liver.". International Journal of Molecular Medicine 3, no. 2 (1999): 215-221. https://doi.org/10.3892/ijmm.3.2.215