The role of CD5-expressing B cells in health and disease (review).

  • Authors:
    • J O Pers
    • C Jamin
    • F Predine-Hug
    • P Lydyard
    • P Youinou
  • View Affiliations

  • Published online on: March 1, 1999     https://doi.org/10.3892/ijmm.3.3.239
  • Pages: 239-284
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Abstract

The CD5(+) B cell population is prominent in early life and produce low avidity and, thereby, polyreactive antibodies. CD5(+) B cells are receptive to cytokines and interleukin-10 seems to be influential in the regulation of some of these CD5(+) B cells. The question of whether CD5 is a marker of activation or a molecule specific for a B cell lineage remains unresolved because evidence in support or against a separate lineage are still a matter for debate. However, we suggest the possibility of different kind of CD5(+) B cells. Indeed, activated CD5(+) B cells do proliferate, following CD5 engagement, while resting CD5(+) B cells do not. Moreover, three ligands for CD5 have, thus far, been identified but their functional effects are yet unknown. CD5(+) B cells probably play a role in setting up the idiotype network, antigen presentation and tolerance induction. B cells of most of the chronic lymphoid leukemias express CD5 molecules and, surprisingly, these cells may be expanded in non-organ-specific autoimmune diseases, such as rheumatoid arthritis or primary Sjögren's syndrome. CD5(+) B cells seems to be involved in the autoantibody production (this does not necessarily imply that pathogenic autoantibodies are produced by CD5(+) B cells) in autoimmune disease and particularly susceptible to transformation in lymphoproliferative disorders. Thus, this B cell population appears to play a key role at the crossroad of the non-organ-specific autoimmune diseases and B lymphoproliferative disorders.

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Mar 1999
Volume 3 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Pers J, Jamin C, Predine-Hug F, Lydyard P and Youinou P: The role of CD5-expressing B cells in health and disease (review).. Int J Mol Med 3: 239-284, 1999
APA
Pers, J., Jamin, C., Predine-Hug, F., Lydyard, P., & Youinou, P. (1999). The role of CD5-expressing B cells in health and disease (review).. International Journal of Molecular Medicine, 3, 239-284. https://doi.org/10.3892/ijmm.3.3.239
MLA
Pers, J., Jamin, C., Predine-Hug, F., Lydyard, P., Youinou, P."The role of CD5-expressing B cells in health and disease (review).". International Journal of Molecular Medicine 3.3 (1999): 239-284.
Chicago
Pers, J., Jamin, C., Predine-Hug, F., Lydyard, P., Youinou, P."The role of CD5-expressing B cells in health and disease (review).". International Journal of Molecular Medicine 3, no. 3 (1999): 239-284. https://doi.org/10.3892/ijmm.3.3.239